What if you could identify high risk patients at the earliest stage of their cardiovascular disease?

VitaK Innovation in Life Science has a strong focus on the development of new Point of Care and In Vitro Diagnostic tests.

The POC testing market is set to reach $40 billion by 2022.

Both fundamental and applied research are the core business of VitaK. We offer our expertise in the form of contract research for third parties.

Worldwide we are the number one laboratory in measuring Matrix Gla Protein (MGP).

VitaK has its own facilities for blood sampling and measuring clinical endpoints in the various human intervention trials that are executed.

VitaK has a substantial investment program to increase its own clinical equipment for in-house clinical endpoint measurements in human intervention trials and clinical trials.

What if you could identify high risk patients at the earliest stage of their cardiovascular disease?

VitaK Innovation in Life Science has a strong focus on the development of new Point of Care and In Vitro Diagnostic tests.

The POC testing market is set to reach $40 billion by 2022.

Both fundamental and applied research are the core business of VitaK. We offer our expertise in the form of contract research for third parties.

Worldwide we are the number one laboratory in measuring Matrix Gla Protein (MGP).

VitaK has its own facilities for blood sampling and measuring clinical endpoints in the various human intervention trials that are executed.

VitaK has a substantial investment program to increase its own clinical equipment for in-house clinical endpoint measurements in human intervention trials and clinical trials.

Scientific-publications of:

– Associate Professor Dr. Cees Vermeer (Founder of VitaK, presently retired)
– Dr. Pamela Kleikers (Vice President R&D)
– Mrs. Marjo Knapen (Operational Director, Ph.D. candidate)
– Professor Dr. Jan Staessen (presently retired)
– Ing. Nivedita Daimiwal (Vice President Technical Officer, PhD student)

Publication list 2017 of Associate Professor Dr. Cees Vermeer & Professor. Dr. Jan Staessen

Published papers:

    1. 1. Vermeer, C., van ’t Hoofd, C., Knapen, M.H.J., Xanthoulea, S. Synthesis of 2-methyl-1,4-naphthoquinones with higher gamma-glutamyl carboxylase activity than MK-4 both in vitro and in vivo. Bioorgan. Medicin. Chem. Lett. 27 (2017) 208-211.
    1. 2. Sardana, M., Vassim, I., Varakantam, S., Kewan, U., Koppula, M.R., Syed, A.A., Beraun, M., Drummen, N.E.A., Vermeer, C., Akers, S.R., Chirinos, J.A. Inactive Matrix Gla-Protein and Arterial Stiffness in Type 2 Diabetes Mellitus. Am. J. Hypertens. 30 (2017) 196-201.
    1. 3. Mayer, O., Seidlerová, J., Wohlfahrt, P., Filipovský, J., Cifkova, R., Cerna, V., Kucerova, A., Pesta, M., Fuchsova, R., Topolcan, O., Jardon, K.M.C., Drummen, N.E.A., Vermeer, C. Synergistic effect of low K and D vitamin status on arterial stiffness in a general population. J. Nutr. Biochem. 46 (2017) 83-89.
    1. 4. Shea, M. K., Booth, S.L., Weiner, D.E., Brinkley, T.E., Kanaya, A.M., Murphy, R., Simonsick, E.M., Wassel, C.L., Vermeer, C., Kritchevsky, S.B. Circulating vitamin K is inversely associated with incident CVD risk among those treated for hypertension in the Healthy Aging and Body Composition study (Health ABC). J. Nutr. 147 (2017) 888-895.
    1. 5. Viegas, C.S.B., Costa, R.M., Santos, L., Videira, P.A., Silva, Z., Araújo, N., Macedo, A.L., Matos, A.A., Vermeer, C., Simes, D.C. Gla-rich protein functions as an anti-inflammatory agent in monocytes/macrophages: implications for calcification-related chronic inflammatory diseases. PLoS ONE 12(5): e0177829.
    1. 6. Nigwekar, S.U., Nazarian, R.M., Bloch, D.B., Vermeer, C., Booth, S.L., Xu, D., Thadhani, R.I., Malhotra, R..Vitamin K-dependent carboxylation of matrix Gla protein influences calciphilaxis risk. J. Am. Soc. Nephrol 28 (2017) 1717-1722
    1. 7. Janssen, R., Vermeer, C. Vitamin K deficit and elastolysis theory in pulmonary elasto-degenerative diseases. Medical Hypotheses 108 (2017) 38-41.
    1. 8. Van Ballegooyen, H., Brouwer, I.A., Visser, M., Nijpels, G., Dekker, J.M., Rennenberg, R.J., Vermeer, C., Stehouwer, C.D., Beulens, J.W. Low vitamin K status is prospectively associated with greater left ventricular mass. Circulation 135 (2017) Suppl. 1, AMP072.
    1. 9. Mayer, O., Seidlerová, J., Wohlfahrt, P., Filipovský, J., Cifkova, R., Cerna, V., Kucerova, A., Pesta, M., Fuchsova, R., Topolcan, O., Jardon, K.M.C., Drummen, N.E.A., Vermeer, C. Synergistic effect of low K and D vitamin status on arterial stiffness in a general population. Journal of Hypertension 35:e73.
    1. 10. Piscaer, I., Janssens, W., Drummen, N.E.A., Vermeersch, K., Serre, J., Vermeer, C., Janssen, R. Total uncarboxylated Matrix Gla Protein associates with airflow obstruction, diffusion limitation and aortic calcification In chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 195 (2017) A7254.
    1. 11. Zwakenberg, S.R., den Braver, N.R., Engelen, A., Feskens, E.J.M., Vermeer, C., Boer, J.M.A., Verschuren, W.M.M., van der Schouw, Y.T., Beulens, J.W.J. Vitamin K intake and all-cause and cause specific mortality. Clin. Nutr. 36 (2017) 1294-1300.
    1. 12. Trenson, S., Wei, F., Ehret, G., Monney, P., Yang, W.Y., Zhang, Z.Y., Huang, Q.F., Thijs, L., Kuznetsova, T., Verhamme, P., Allegaert, K., Vermeer, C., Janssens, S., Bochud, M., Staessen, J. The association of left ventricular diastolic function with inactive matrix Gla protein: from epidemiology to histopathology. Eur. Heart J. 38 Suppl. 1 (2017) 1307.
    1. 13. Piscaer, I., Wouters, E.F.M. Vermeer, C., Janssens, W., Franssen, F.M.E., Janssen, R., Vitamin K Deficiency: The Linking Pin Between COPD and Cardiovascular Diseases? Resp. Res.18 (2017) 189; DOI 10.1186/s12931-017-0673-z.
    1. 14. Zwakenberg, S.R., Engelen, A.I.P., Dalmeijer, G.W., Booth, S.L., Vermeer, C., Drijvers, J., Ocke, M.C., Feskens, E.J.M. , van der Schouw, Y.T., Beulens, J.W.J. Reproducibility and relative validity of a food frequency questionnaire to estimate intake of dietary phylloquinone and menaquinones. Eur. J. Nutr. 71 (2017) 1423-1428.
    1. 15. Riphagen, I.J., Keyzer, C.A., de Borst, M., Gansevoort, R.T., Geleijnse, J.M.,Muskiet, F.A.J., Navis, G., Visser, S.T., Vermeer, C., Kema, I.P., Bakker, S.J.L. Prevalence and effects of functional vitamin K insufficiency in the general population: The PREVEND study. Nutrients.9 (2017) 1334; doi:10.3390/nu9121334.
    1. 16. Viegas, C. Santos, L., Macedo, A., Morais, R., Silva, A., Neves, P., Matos, A., Vermeer, C., Simes, D. Circulating calciprotein particles and extracellular vesicles as novel players in chronic kidney disease vascular calcification. A role for Gla-rich protein. Nephrol. Dial. Transplant. 32 Suppl. 3 (2017) iii67–iii68.
    1. 17. Yang, W.Y., Petit, T., Cauwenberghs, N., Zhang, Z.Y., Sheng, C.S., Thijs, L., Salvi, E., Izzi, B., Vandenbriele, C., Wei, F.F., Gu, Y.M., Jacobs, L., Citterio, L., Delli Carpini, S., Barlassina, C., Cusi, D., Hoylaerts, M.F., Verhamme, P., Kuznetsova, T., Staessen, J.A. PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population. BMC Med. Genet. 18:45 (2017) doi: 10.1186/s12881-017-0411-x.
    1. 18. Melgarejo, J.D., Maestre, G.E., Thijs, L., Asayama, K., Boggia, J., Casiglia, E., Hansen, T.W., Imai, Y., Jacobs, L., Jeppesen, J., Kawecka-Jaszcz, K., Kuznetsova, T., Li, Y., Malyutina, S., Nikitin, Y., Ohkubo, T., Stolarz-Skrzypek, K., Wang, J.G., Staessen, J.A. Prevalence, Treatment, and Control Rates of Conventional and Ambulatory Hypertension Across 10 Populations in 3 Continents. Hypertension 70 (2017) 50-58.
    1. 19. Jacobs, L., Persu, A., Huang, Q.F., Lengelé, J.P., Thijs, L., Hammer, F., Yang, W.Y., Zhang, Z.Y., Renkin, J., Sinnaeve, P., Wei, F.F., Pasquet, A., Fadl Elmula, F.E.M., Carlier, M., Elvan, A., Wunder, C., Kjeldsen, S.E., Toennes, S.W., Janssens, S., Verhamme, P., Staessen, J.A.; European Network Coordinating Research on Renal Denervation. Results of a randomized controlled pilot trial of intravascular renal denervation for management of treatment-resistant hypertension. Blood Press 28 (2017) 321-331.
    1. 20. Yang, W.Y., Zhang, Z.Y., Thijs, L., Bijnens, E.M., Janssen, B.G., Vanpoucke, C., Lefebvre, W., Cauwenberghs, N., Wei, F.F., Luttun, A., Verhamme, P., Van Hecke, E., Kuznetsova, T., D’hooge, J., Nawrot, T.S., Staessen, J.A. Left ventricular function in relation to chronic residential air pollution in a general population. Eur. J. Prev. Cardiol. 24 (2017) 1416-1428.
    1. 21. Zhang ZY, Ravassa S, Nkuipou-Kenfack E, Yang WY, Kerr SM, Koeck T, Campbell A, Kuznetsova T, Mischak H, Padmanabhan S, Dominiczak AF, Delles C, Staessen JA. Novel Urinary Peptidomic Classifier Predicts Incident Heart Failure. J Am Heart Assoc. 6 (2017) pii: e005432. doi: 10.1161/JAHA.116.005432.
    1. 22. Cheng, Y.B., Li, L.H., Guo, Q.H., Li, F.K., Huang, Q.F., Sheng, C.S., Wang, J.G., Staessen, J.A., Li, Y. Independent effects of blood pressure and parathyroid hormone on aortic pulse wave velocity in untreated Chinese patients. J. Hypertens.35 (2017) 1841-1848.
    1. 23. Justice, A.E., Winkler, T.W., Feitosa, M.F., Graff, M., Fisher, V.A., Young, K., Barata, L., Deng, X., Czajkowski, J., Hadley, D., Ngwa, J.S., Ahluwalia, T.S., Chu, A.Y., Heard-Costa, N.L., Lim, E., Perez, J., Eicher, J.D., Kutalik, Z., Xue, L., Mahajan, A., Renström, F., Wu, J., Qi, Q., Ahmad, S., Alfred, T., Amin, N., Bielak, L.F., Bonnefond, A., Bragg, J., Cadby, G., Chittani, M., Coggeshall, S., Corre, T., Direk, N., Eriksson, J., Fischer, K., Gorski, M., Neergaard Harder, M., Horikoshi, M., Huang, T., Huffman, J.E., Jackson, A.U., Justesen, J.M., Kanoni, S., Kinnunen, L., Kleber, M.E., Komulainen, P., Kumari, M., Lim, U., Luan, J., Lyytikäinen, L.P., Mangino, M., Manichaikul, A., Marten, J., Middelberg, R.P.S., Müller-Nurasyid, M., Navarro, P., Pérusse, L., Pervjakova, N., Sarti, C., Smith, A.V., Smith, J.A., Stančáková, A., Strawbridge, R.J., Stringham, H.M., Sung, Y.J., Tanaka, T., Teumer, A., Trompet, S., van der Laan, S.W., van der Most, P.J., Van Vliet-Ostaptchouk, J.V., Vedantam, S.L., Verweij, N., Vink, J.M., Vitart, V., Wu, Y., Yengo, L., Zhang, W., Hua Zhao, J., Zimmermann, M.E., Zubair, N., Abecasis, G.R., Adair, L.S., Afaq, S., Afzal, U., Bakker, S.J.L., Bartz, T.M., Beilby, J., Bergman, R.N., Bergmann, S., Biffar, R., Blangero, J., Boerwinkle, E., Bonnycastle, L.L., Bottinger, E., Braga, D., Buckley, B.M., Buyske, S., Campbell, H., Chambers, J.C., Collins, F.S., Curran, J.E., de Borst, G.J., de Craen, A.J.M., de Geus, E.J.C., Dedoussis, G., Delgado, G.E., den Ruijter, H.M., Eiriksdottir, G., Eriksson, A.L., Esko, T., Faul, J.D., Ford, I., Forrester, T., Gertow, K., Gigante, B., Glorioso, N., Gong, J., Grallert, H., Grammer, T.B., Grarup, N., Haitjema, S., Hallmans, G., Hamsten, A., Hansen, T., Harris, T.B., Hartman, C.A., Hassinen, M., Hastie, N.D., Heath, A.C., Hernandez, D., Hindorff, L., Hocking, L.J., Hollensted, M., Holmen, O.L., Homuth, G., Jan Hottenga, J., Huang, J., Hung, J., Hutri-Kähönen, N., Ingelsson, E., James, A.L., Jansson, J.O., Jarvelin, M.R., Jhun, M.A., Jørgensen, M.E., Juonala, M., Kähönen, M., Karlsson, M., Koistinen, H.A., Kolcic, I., Kolovou, G., Kooperberg, C., Krämer, B.K., Kuusisto, J., Kvaløy, K., Lakka, T.A., Langenberg, C., Launer, L.J., Leander, K., Lee, N.R., Lind, L., Lindgren, C.M., Linneberg, A., Lobbens, S., Loh, M., Lorentzon, M., Luben, R., Lubke, G., Ludolph-Donislawski, A., Lupoli, S., Madden, P.A.F., Männikkö, R., Marques-Vidal, P., Martin, G., McKenzie, C.A., McKnight, B., Mellström, D., Menni, C., Montgomery, G.W., Musk, A.B., Narisu, N., Nauck, M., Nolte, I.M., Oldehinkel, A.J., Olden, M., Ong, K.K., Padmanabhan, S., Peyser, P.A., Pisinger, C., Porteous, D.J., Raitakari, O.T., Rankinen, T., Rao, D.C., Rasmussen-Torvik, L.J., Rawal, R., Rice, T., Ridker, P.M., Rose, L.M., Bien, S.A., Rudan, I., Sanna, S., Sarzynski, M.A., Sattar, N., Savonen, K., Schlessinger, D., Scholtens, S., Schurmann, C., Scott, R.A., Sennblad, B., Siemelink, M.A., Silbernagel, G., Slagboom, P.E., Snieder, H., Staessen, J.A., Stott, D.J., Swertz, M.A., Swift, A.J., Taylor, K.D., Tayo, B.O., Thorand, B., Thuillier, D., Tuomilehto, J., Uitterlinden, A.G., Vandenput, L., Vohl, M.C., Völzke, H., Vonk, J.M., Waeber, G., Waldenberger, M., Westendorp, R.G.J., Wild, S., Willemsen, G., Wolffenbuttel, B.H.R., Wong, A., Wright, A.F., Zhao, W., Zillikens, M.C., Baldassarre, D., Balkau, B., Bandinelli, S., Böger, C.A., Boomsma, D.I., Bouchard, C., Bruinenberg, M., Chasman, D.I., Chen, Y.D., Chines, P.S., Cooper, R.S., Cucca, F., Cusi, D., Faire, U., Ferrucci, L., Franks, P.W., Froguel, P., Gordon-Larsen, P., Grabe, H.J., Gudnason, V., Haiman, C.A., Hayward, C., Hveem, K., Johnson, A.D., Wouter Jukema, J., Kardia, S.L.R., Kivimaki, M., Kooner, J.S., Kuh, D., Laakso, M., Lehtimäki, T., Marchand, L.L., März, W., McCarthy, M.I., Metspalu, A., Morris, A.P., Ohlsson, C., Palmer, L.J., Pasterkamp, G., Pedersen, O., Peters, A., Peters, U., Polasek, O., Psaty, B.M., Qi, L., Rauramaa, R., Smith, B.H., Sørensen, T.I.A., Strauch, K., Tiemeier, H., Tremoli, E., van der Harst, P., Vestergaard, H., Vollenweider, P., Wareham, N.J., Weir, D.R., Whitfield, J.B., Wilson, J.F., Tyrrell, J., Frayling, T.M., Barroso, I., Boehnke, M., Deloukas, P., Fox, C.S., Hirschhorn, J.N., Hunter, D.J., Spector, T.D., Strachan, D.P., van Duijn, C.M., Heid, I.M., Mohlke, K.L., Marchini, J., Loos, R.J.F., Kilpeläinen, T.O., Liu, C.T., Borecki, I.B., North, K.E., Cupples, L.A. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Commun. 8 (2017) 14977. doi: 10.1038/ncomms14977.
    1. 24. Fadl Elmula, F.E.M., Feng, Y.M., Jacobs, L., Larstorp, A.C., Kjeldsen, S.E., Persu, A., Staessen, J.A., European Network COordinating research on Renal Denervation (ENCOReD). Sham or no sham control: that is the question in trials of renal denervation for resistant hypertension. A systematic meta-analysis. Blood Press. 2017 doi: 10.1080/08037051.2017.1311769.
    1. 25. Nomura K, Asayama K, Jacobs L, Thijs L, Staessen JA. Renal function in relation to sodium intake: a quantitative review of the literature. Kidney Int. 92 (2017) 67-78.
    1. 26. Raaijmakers, A., Jacobs, L., Rayyan, M., van Tienoven, T.P., Ortibus, E., Levtchenko, E., Staessen, J.A., Allegaert, K. Catch-up growth in the first two years of life in Extremely Low Birth Weight (ELBW) infants is associated with lower body fat in young adolescence. PLoS One 12(3) (2017) e0173349.
    1. 27. Htun, N.M., Magliano, D.J., Zhang, Z.Y., Lyons, J., Petit, T., Nkuipou-Kenfack, E., Ramirez-Torres, A., von Zur Muhlen, C., Maahs, D., Schanstra, J.P., Pontillo, C., Pejchinovski, M., Snell-Bergeon, J.K., Delles, C., Mischak, H., Staessen, J.A., Shaw, J.E., Koeck, T., Peter, K. Prediction of acute coronary syndromes by urinary proteome analysis. PLoS One 12(3) (2017) e0172036.
    1. 28. Juhanoja, E.P., Niiranen, T.J., Johansson, J.K., Puukka, P.J., Thijs, L., Asayama, K., Langén, V.L., Hozawa, A., Aparicio, L.S., Ohkubo, T., Tsuji, I., Imai, Y., Stergiou, G.S., Jula, A.M., Staessen, J.A. Outcome-Driven Thresholds for Increased Home Blood Pressure Variability. Hypertension 69 (2017) 599-607.
    1. 29. Yang, W.Y., Zhang, Z.Y., Thijs, L., Cauwenberghs, N., Wei, F.F., Jacobs, L., Luttun, A., Verhamme, P., Kuznetsova, T., Nawrot, T.S., Staessen, J.A. Left Ventricular Structure and Function in Relation to Environmental Exposure to Lead and Cadmium. J Am Heart Assoc. 6 (2017) pii: e004692. doi: 10.1161/JAHA.116.004692.
    1. 30. Raaijmakers, A., Zhang, Z.Y., Claessens, J., Cauwenberghs, N., van Tienoven, T.P., Wei, F.F., Jacobs, L., Levtchenko, E., Pauwels, S., Kuznetsova, T., Allegaert, K., Staessen, J.A. Does Extremely Low Birth Weight Predispose to Low-Renin Hypertension? Hypertension 69 (2017) 443-449.
    1. 31. Staessen, J.A., Li, Y., Hara, A., Asayama, K., Dolan, E., O’Brien, E. Blood Pressure Measurement Anno 2016. Am. J. Hypertens. 30 (2017) 453-463.
    1. 32. Sheng, C.S., Cheng, Y.B., Wei, F.F., Yang, W.Y., Guo, Q.H., Li, F.K., Huang, Q.F., Thijs, L., Staessen, J.A., Wang, J.G., Li, Y. Diurnal Blood Pressure Rhythmicity in Relation to Environmental and Genetic Cues in Untreated Referred Patients. Hypertension 69 (2017) 128-135.
    1. 33. Pontillo, C., Jacobs, L., Staessen, J.A., Schanstra, J.P., Rossing, P., Heerspink, H.J., Siwy, J., Mullen, W., Vlahou, A., Mischak, H., Vanholder, R., Zürbig, P., Jankowski, J. A urinary proteome-based classifier for the early detection of decline in glomerular filtration. Nephrol Dial Transplant. 32 (2016) 1510-1516.
    1. 34. Asayama K, Li Y, Franklin SS, Thijs L, O’Brien E, Staessen JA. Cardiovascular Risk Associated With White-Coat Hypertension: Con Side of the Argument. Hypertension 70 (2017) 676-682.
    1. 35. Efremov L, Yang WY, Jacobs L, Thijs L, Kuznetsova T, Struijker-Boudier HAJ, Staessen JA. Post-processing reproducibility of the structural characteristics of the common carotid artery in a Flemish population. Artery Res. 19 (2017) 9-17.
    1. 36. Malhotra R, Nguyen HA, Benavente O, Mete M, Howard BV, Mant J, Odden MC, Peralta CA, Cheung AK, Nadkarni GN, Coleman RL, Holman RR, Zanchetti A, Peters R, Beckett N, Staessen JA, Ix JH. Association Between More Intensive vs Less Intensive Blood Pressure Lowering and Risk of Mortality in Chronic Kidney Disease Stages 3 to 5: A Systematic Review and Meta-analysis. JAMA Intern Med. 177 (2017) 1498-1505.
    1. 37. Huang QF, Trenson S, Zhang ZY, Yang WY, Van Aelst L, Nkuipou-Kenfack E, Wei FF, Mujaj B, Thijs L, Ciarka A, Zoidakis J, Droogné W, Vlahou A, Janssens S, Vanhaecke J, Van Cleemput J, Staessen JA. Urinary Proteomics in Predicting Heart Transplantation Outcomes (uPROPHET)-Rationale and database description. PLoS One. 12 (2017) e0184443. doi: 10.1371/journal.pone.0184443. eCollection 2017.
    1. 38. Moulin F, Ponte B, Pruijm M, Ackermann D, Bouatou Y, Guessous I, Ehret G, Bonny O, Pechère-Bertschi A, Staessen JA, Paccaud F, Martin PY, Burnier M, Vogt B, Devuyst O, Bochud M. A population-based approach to assess the heritability and distribution of renal handling of electrolytes. Kidney Int. 92 (2017) 1536-1543.
    1. 39. Zhang ZY, Ravassa S, Pejchinovski M, Yang WY, Zürbig P, López B, Wei FF, Thijs L, Jacobs L, González A, Voigt JU, Verhamme P, Kuznetsova T, Díez J, Mischak H, Staessen JA. A Urinary Fragment of Mucin-1 Subunit α Is a Novel Biomarker Associated With Renal Dysfunction in the General Population. Kidney Int Rep. 2 (2017) 811-820.
    1. 40. Odili AN, Thijs L, Yang WY, Ogedengbe JO, Nwegbu MM, Jacobs L, Wei FF, Feng YM, Zhang ZY, Kuznetsova T, Nawrot TS, Staessen JA. Office and Home Blood Pressures as Determinants of Electrocardiographic Left Ventricular Hypertrophy Among Black Nigerians Compared With White Flemish. Am J Hypertens. 30 (2017) 1083-1092.
    41. Pontillo C, Zhang ZY, Schanstra JP, Jacobs L, Zürbig P, Thijs L, Ramírez-Torres A, Heerspink HJL, Lindhardt M, Klein R, Orchard T, Porta M, Bilous RW, Charturvedi N, Rossing P, Vlahou A, Schepers E, Glorieux G, Mullen W, Delles C, Verhamme P, Vanholder R, Staessen JA, Mischak H, Jankowski J. Prediction of Chronic Kidney Disease Stage 3 by CKD273, a Urinary Proteomic Biomarker. Kidney Int Rep. 2 (2017) 1066-1075.
Publication list of Dr. Pamela Kleikers

Published papers:

  1. 1 Langhauser, F., Casas, A. I., Dao, V. T., Guney, E., Menche, J., Geuss, E., Kleikers, P. W. M., Lopez, M. G., Barabasi, A. L., Kleinschnitz, C. & Schmidt, H. A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection. NPJ systems biology and applications 4, 8, doi:10.1038/s41540-017-0039-7 (2018).2 Casas, A. I., Geuss, E., Kleikers, P. W. M., Mencl, S., Herrmann, A. M., Buendia, I., Egea, J., Meuth, S. G., Lopez, M. G., Kleinschnitz, C. & Schmidt, H. NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage. Proceedings of the National Academy of Sciences of the United States of America 114, 12315-12320, doi:10.1073/pnas.1705034114 (2017).

    3 Oettrich, J. M., Dao, V. T., Frijhoff, J., Kleikers, P., Casas, A. I., Hobbs, A. J. & Schmidt, H. H. Clinical relevance of cyclic GMP modulators: A translational success story of network pharmacology. Clinical pharmacology and therapeutics 99, 360-362, doi:10.1002/cpt.336 (2016).

    4 Kleinschnitz, C., Mencl, S., Kleikers, P. W., Schuhmann, M. K., M, G. L., Casas, A. I., Surun, B., Reif, A. & Schmidt, H. H. NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 36, 1508-1512, doi:10.1177/0271678×16657094 (2016).

    5 Kleikers, P. W., Hooijmans, C., Gob, E., Langhauser, F., Rewell, S. S., Radermacher, K., Ritskes-Hoitinga, M., Howells, D. W., Kleinschnitz, C. & Schmidt, H. H. A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation. Scientific reports 5, 13428, doi:10.1038/srep13428 (2015).

    6 Altenhofer, S., Radermacher, K. A., Kleikers, P. W., Wingler, K. & Schmidt, H. H. Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement. Antioxidants & redox signaling 23, 406-427, doi:10.1089/ars.2013.5814 (2015).

    7 Kleikers, P. W., Dao, V. T., Gob, E., Hooijmans, C., Debets, J., van Essen, H., Kleinschnitz, C. & Schmidt, H. H. SFRR-E Young Investigator AwardeeNOXing out stroke: Identification of NOX4 and 5as targets in blood-brain-barrier stabilisation and neuroprotection. Free radical biology & medicine 75 Suppl 1, S16, doi:10.1016/j.freeradbiomed.2014.10.593 (2014).

    8 Radermacher, K. A., Wingler, K., Langhauser, F., Altenhofer, S., Kleikers, P., Hermans, J. J., Hrabe de Angelis, M., Kleinschnitz, C. & Schmidt, H. H. Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress. Antioxidants & redox signaling 18, 1418-1427, doi:10.1089/ars.2012.4797 (2013).

    9 Wingler, K., Altenhoefer, S. A., Kleikers, P. W., Radermacher, K. A., Kleinschnitz, C. & Schmidt, H. H. VAS2870 is a pan-NADPH oxidase inhibitor. Cellular and molecular life sciences : CMLS 69, 3159-3160, doi:10.1007/s00018-012-1107-1 (2012).

    10 Radermacher, K. A., Wingler, K., Kleikers, P., Altenhofer, S., Jr Hermans, J., Kleinschnitz, C. & Hhw Schmidt, H. The 1027th target candidate in stroke: Will NADPH oxidase hold up? Experimental & translational stroke medicine 4, 11, doi:10.1186/2040-7378-4-11 (2012).

    11 Kleikers, P. W., Wingler, K., Hermans, J. J., Diebold, I., Altenhofer, S., Radermacher, K. A., Janssen, B., Gorlach, A. & Schmidt, H. H. NADPH oxidases as a source of oxidative stress and molecular target in ischemia/reperfusion injury. Journal of molecular medicine (Berlin, Germany) 90, 1391-1406, doi:10.1007/s00109-012-0963-3 (2012).

    12 Altenhofer, S., Kleikers, P. W., Radermacher, K. A., Scheurer, P., Rob Hermans, J. J., Schiffers, P., Ho, H., Wingler, K. & Schmidt, H. H. The NOX toolbox: validating the role of NADPH oxidases in physiology and disease. Cellular and molecular life sciences : CMLS 69, 2327-2343, doi:10.1007/s00018-012-1010-9 (2012).

    13 van der Sterren, S., Kleikers, P., Zimmermann, L. J. & Villamor, E. Vasoactivity of the gasotransmitters hydrogen sulfide and carbon monoxide in the chicken ductus arteriosus. American journal of physiology. Regulatory, integrative and comparative physiology 301, R1186-1198, doi:10.1152/ajpregu.00729.2010 (2011).

    14 van der Sluijs-Bens, J. P. & Kleikers, P. W. [A premature with nail defects]. Nederlands tijdschrift voor geneeskunde 154, A205 (2010).

Publication list of Marjo Knapen

Published papers:

Publication list of Ing. Nivedita Daimiwal

Published papers:

  1. 1 Revati Shriram, Betty Martin, M. Sundhararajan, Nivedita Daimiwal. Comparison of Acceleration Plethysmogram Acquired using Optical Signal and Pressure Signal. International Journal of Signal Processing, Image Processing and Pattern Recognition, Science and Engineering Research Support Society (SERSC). 2017 Sep;10(9): 57-68. ISSN: 20054254 (SJR: 0.112)2 Revati Shriram, Betty Martin, M. Sundhararajan, Nivedita Daimiwal. Future of CPPG – EEG Concurrent Modality. International Journal on Intelligent Electronic Systems. 2017 Jan;11(1):19-26. ISSN: Sathyabama University.

    3 Nivedita Daimiwal, Dr. Betty Martin, Dr.M.Sundhararajan, Revati Shriram. Design and implementation of cranial PPG sensor for brain mapping using fMRI as gold standard. International Journal on Intelligent Electronics Systems. 2017 Jan;11(1).

    4 Revati Shriram, M. Sundhararajan, Supriya Shete, Nivedita Daimiwal. Statistical Features based comparison of Analysis and Synthesis of Normal and Epileptic Electroencephalogram for various Wavelets. Turkish Journal of Electrical Engineering and Computer Sciences, Scientific and Technological Research Council of Turkey. 2017;25(3):1795-1806. ISSN:13000632. (SNIP:0.621, SJR:0.311)

    5 Nivedita Daimiwal, Dr. Betty Martin, Dr. M. Sundararajan, Revati Shriram.Analysis of radio frequency reflectance type PPG sensor based on systolic amplitude and source wavelength. Biomedical Research 2016; Special Issue:S371-S375. ISSN:0970-938X (SNIP:0.225, SJR: 0.162,IPP: 0.315).

    6 Revati Shriram, Betty Martin, M. Sundhararajan, Nivedita Daimiwal. Effect of Source Wavelength on Second Derivative of Finger Photoplethysmogram in Healthy Young Female Volunteers. Biomedical Research-India, Allied Academics, Special Issue: Health Science and Bio Convergence Technology: Edition-I. 2016 Dec;25:S454-S459. ISSN: 0970-938X. (SNIP:0.215, SJP:0.162, IPP:0.315)

    7 Nivedita Daimiwal, M.Sundhararajan, Revati Shriram. Non Invasive Measurement and Analysis of Cardiac Output for Different Age Group Using PPG Sensor. International Journal of Compute applications. 2016: 25-28. ISSN: 0975-8887. ISBN:973-93-80892-27-1.

    8 Nivedita Daimiwal, Dr.M.Sundhararajan, Revati Shriram. NIRS Based PPG Sensor For Detection of Oxy –Hb and Deoxy-Hb Change During Activity. International Journal of Applied Engineering Research, Research India Publications. 2015; 10(7):17347-17356. ISSN 0973-4562. (SNIP:0.260, SJR: 0.130,IPP: 0.105).

    9 Nivedita Daimiwal, M.Sundhararajan , Revati Shriram. Design of Cranial PPG sensor for DC and PWM Excitation in Near Infrared Spectroscopy. IJCTA, International Sciences Press. 2015;8(3):971-975. ISSN:0974-5572 (SNIP:1.466, SJR: 0.526,IPP: 11.171).

    10 Revati Shriram, M. Sundhararajan, Nivedita Daimiwal. Statistical Analysis of Pulse Acquired from various Body sites using Piezoelectric and Optical Transduce.,International Journal of Control Theory and Applications (IJCTA), Serial Publications. 2015;8(3):831-838. ISSN:0974-5572. (SNIP:1.466, SJR:0.526 IPP:11.171)

    11 Revati Shriram, M. Sundhararajan, Nivedita Daimiwal. Cranial PPG Brain Signal based Cardiovascular Parameter Estimation., International Journal of Control Theory and Applications (IJCTA), Serial Publications. 2015;8(3):839-845. ISSN:0974-5572. (SNIP:1.466, SJR:0.526 IPP:11.171)

    12 Nivedita Daimiwal, M.Sundhararajan, Revati Shriram. Human Brain Mapping based on COLD Signal Hemodynamic Response and Electrical Neuroimaging. International Journal of Computer Applications (IJCA). 2013 Feb;63(5): 27-31. ISSN:0975-8887.

    13 Nivedita Daimiwal, M.Sundhararajan, Revati Shriram. Non Invasive FNIR and FMRI system for Brain Mapping. IJSRP (International Journal of Scientific and Research Publications). 2013 Feb;3(2):1-4. ISSN: 2250-3153.

    14 Nivedita Daimiwal, M.Sundhararajan, Revati Shriram.Applications of fMRI for Brain Mapping. (IJCSIS) International Journal of Computer Science and Information Security. 2012 Nov;10(11):23-27. ISSN: 19475500.

    15 Nivedita Daimiwal, M.Sundhararajan, Revati Shriram. Functional MRI Study for Eye Blinking and Finger Tapping. IOSR Journal of Electronics and Communication Engineering (IOSR-JECE). PP: 22-26. ISSN: 2278-2834. ISBN: 2278-8735.

    16 Nivedita Daimiwal, M.Sundhararajan, Revati Shriram. Brain Connectivity Analysis Methods for Better Understanding of Coupling. International Journal of Computer Science and Information Security (IJCSIS). 2012 Nov;10(11):16-22. ISSN:1947-5500.

Publication list 2016 of Associate Professor Dr. Cees Vermeer & Professor. Dr. Jan Staessen

Published papers:

  1. Engelen, L., Bossuyt, J., Ferreira, I., van Bortel, L.M., Reesink, K.D., Segers, P., Stehouwer, C.D., Laurent, S., Boutouyrie, P. Mattace-Raso, F.U.S., Hofman, A., Franco, O.H., Kavousi, M., van Rooij, F.J.A., Jouven, X., Empana, J.-P., Bozec, E., Khettab, H., Simon, T., Pannier, B., Bots, M.L., Grobbee, D.E., Uiterwaal, C.S., Evelein, A., van der Graaf, Y., Visseren, F.L.J., Rietzschel, E., De Bacquer, D., Vandaele, C., De Buyzere, M., Dekker, J., Nijpels, G., Twisk, J., Smulders, Y., Schalkwijk, C., van Greevenbroek, M., van der Kallen, C., van de Laar, R., Feskens, E., Staessen, J.A., Thijs, L., Kouznetsova, T., Jin, Y., Liu, Y., Wang, J., Li, Y., Bianchini, E., Ghiadoni, L., Bruno, R.M., Pratali, L., Taddei, S., Fischer, J., Terris, D., Jarczok, M., Thole, M., Ryliskyte, L., Laucevicius, A., Ryliskiene, K., Kuzmickiene, J., Heuten, H., Goovaerts, I., Ennekens, G., Vrints, C., Tolezani, E.C., Hong, V., Bortolotto, L., Benetos, A., Labat, C., Lacolley, P., Rimoldi, S.F., Stucki, F., Hutter, D., Rexhaj, E., Faita, F., Sartori, C., Scherrer, U., Allemann, Y., Giannattasio, C., Nava, S., Maloberti, A., Meani, P., Vermeer, C., Knapen, M.H.J., Drummen, N.A.E., Kollai, M., Pintér, A., Horváth, T., Thuillez, C., Joannidès, R., Bellien, J., Delahousse, M., Karras, A., Vanmolkot, F., de Hoon, J., Narkiewicz, K., Szyndler, A., Hoffmann, M., Nowak, R., Polonis, K., Filipovský, J., Agharazii, M., Briet, M. et al Reference values for local arterial stiffness. Part A: carotid artery. J. Hypertension 33 (2015) 1981-1996.
  2. Mayer, O. Seidlerová, J., Vaněk, J., Vagovičová; P., Bruthans, J., Filipovský, J., Wohlfahrt, P., Cífková, R., Windrichová, J., Knapen, M.H.J., Drummen, N.E.A., Vermeer, C. The abnormal status of uncarboxylated matrix Gla-protein species represents an additive mortality risk in heart failure patients with stable vascular disease. Int. J. Cardiol. 203 (2016) 916-922.
  3. Persu, A., Kjeldsen, S., Staessen, J.A., Azizi, M. Renal denervation for treatment of hypertension: a second start and new challenges. Curr. Hypertens. Rep. 6 (2016) doi: 10.1007/s11906-015-0610-9.
  4. Hara, A., Yang, W.Y., Petit, T., Zhang, Z.Y., Gu, Y.M., Wei, F.F., Jacobs, L., Odili, A.N., Thijs, L., Nawrot, T.S., Staessen, J.A. Incidence of nephrolithiasis in relation to environmental exposure to lead and cadmium in a population study. Environ. Res. 145 (2015) 1-8.
  5. Cavaco, S., Carla S. B. Viegas, C.S.B., Rafael, M.S., Ramos, A., Magalhães, J., Blanco, F.J., Vermeer, C., Simes, D.C. Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis. Cell. Mol. Life Sci. 73 (2016)1051-1065.
  6. Fulton, R.L., McMurdo, M.E.T., Hill, A., Abboud, R.J., Arnold, G.P., Struthers, A.D., Khan, F., Vermeer, C., Knapen, M.H.J., Drummen, N., Witham, M.D. Effect of vitamin K on vascular health and physical function in older people with vascular disease. J. Nutr. Health Aging 20 (2016) 325-233..
  7. Wei, F.-F., Drummen, N.E.A., Schutte, A.E., Thijs, L., Jacobs, L., Petit, T., Yang, W.-Y., Smith, W., Zhang, Z.-Y., Gu, Y.-M., Kuznetsova, T., Verhamme, P., Allegaert, K., Schutte, R., Lerut, E., Evenepoel, P., Vermeer, C., Staessen, J.A. Vitamin K dependent protection of renal function in multi-ethnic population studies. E-Biomedicine 4 (2016) 162-169.
  8. Manunta P, Ferrandi M, Cusi D, Ferrari P, Staessen J, Bianchi G. Personalized Therapy of Hypertension: the Past and the Future. Curr Hypertens Res. 18 (2016) 24. doi: 10.1007/s11906-016-0632-y.
  9. Gu, Y.M., Petit, T., Wei, F.F., Thijs, L., Jacobs, L., Zhang, Z.Y., Yang, W.Y., Cauwenberghs, N., Knez, J., Struijker-Boudier, H.A., Kuznetsova, T., Verhamme, P., Staessen, J.A. Renal glomerular dysfunction in relation to retinal arteriolar narrowing and high pulse pressure in seniors. Hypertens. Res. 39 (2015) 138-143.
  10. Wei, F.F., Li, Y., Zhang, L., Shan, X.L., Cheng, Y.B., Wang, J.G., Yang, C.H., Staessen, J.A. Persistence of Masked Hypertension in Chinese Patients. Am .J, Hypertens.. 29 (2016) 326-331.
  11. Zhang, Z.Y., Marrachelli, V.G., Thijs, L., Yang, W.Y., Wei, F.F., Monleon, D., Jacobs, L., Nawrot, T., Verhamme, P., Voigt, J.U., Kuznetsova, T., Redón, J., Staessen, J.A. Diastolic left ventricular function in relation to circulating metabolic biomarkers in a general population. J Am Heart Assoc. 29 (2016) pii: e002681.
  12. Asayama, K., Ohkubo, T., Hanazawa, T., Watabe, D., Hosaka, M., Satoh, M., Yasui, D., Staessen, J.A., Imai, Y. for the Hypertensive Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED‐BP) Study Investigators. Does Antihypertensive Drug Class Affect Day-to-Day Variability of Self-Measured Home Blood Pressure? The HOMED-BP Study. J Am Heart Assoc. 23 (2016). pii: e002995.
  13. Tie, J.-K, Carneiro, J.D., Jin, D.-Y., Martinhago, C.D., Vermeer, C., Stafford, D.W.Characterization of vitamin K-dependent carboxylase mutations that cause bleeding and non-bleeding disorders. Blood 17 (2016) 1847-1855.
  14. Kurnatowska, I., Grzelak, P., Masajtis-Zagajewska, A., Kaczmarska, M., Stefańczyk, L., Vermeer, C., Maresz, K., Nowicki, M. Plasma Desphospho-Uncarboxylated Matrix Gla Protein as a Marker of Kidney Damage and Cardiovascular Risk in Advanced Stage of Chronic Kidney Disease. Kidney Blood Press. Res. 41 (2016) 231-239.
  15. Persu A, Evenepoel L, Jin Y, Mendola A, Ngueta G, Yang WY, Gruson D, Horman S, Staessen JA, Vikkula M; BELHYPGEN Consortium. STK39 and WNK1 Are Potential Hypertension Susceptibility Genes in the BELHYPGEN Cohort. Medicine (Baltimore) 95 (2016) e2968.
  16. Feng YM, Zhao D, Zhang N, Yu CG, Zhang Q, Thijs L, Staessen JA. Insulin Resistance in Relation to Lipids and Inflammation in Type-2 Diabetic Patients and Non-Diabetic People. PLoS One. 11 (2016) e0153171.
  17. de Jong, M.R., Hoogerwaard, A.F., Gal, P., Adiyaman, A., Smit, J.J., Delnoy, P.P., Ramdat Misier, A.R., van Hasselt, B.A., Heeg, J.E., le Polain de Waroux, J.B., Lau, E.O., Staessen, J.A., Persu, A., Elvan, A. Persistent increase in blood pressure after renal nerve stimulation in accessory renal arteries after sympathetic renal denervation. Hypertension 67 (2016) 1211-1217.
  18. Boggia, J., Luzardo, L., Lujambio, I., Sottolano, M., Robaina, S., Thijs, L., Olascoaga, A., Noboa, O., Struijker-Boudier, H.A., Safar, M.E., Staessen, J.A. The Diurnal Profile of Central Hemodynamics in a General Uruguayan Population. Am. J. Hypertens. 29 (2016) 737-746.
  19. Odili AN, Thijs L, Hara A, Wei FF, Ogedengbe JO, Nwegbu MM, Aparicio LS, Asayama K, Niiranen TJ, Boggia J, Luzardo L, Jacobs L, Stergiou GS, Johansson JK, Ohkubo T, Jula AM, Imai Y, O’Brien E, Staessen JA. Prevalence and Determinants of Masked Hypertension Among Black Nigerians Compared With a Reference Population. Hypertension 67 (2016) 1249-1255.
  20. Kaesler, N., Immendorf, S., Ouyang, C., Herfs, M., Drummen, N., Carmeliet, P., Vermeer, C., Floege, J., Krüger, T., Schlieper, G. Gas6 protein: Its role in cardiovascular calcification. BMC Nephrology (2016) 17:52 DOI 10.1186/s12882-016-0265-z.
  21. Okbay, A., Beauchamp, J.P., Fontana, M.A., Lee, J.J., Pers, T.H., Rietveld, C.A., Turley, P., Chen, G.B., Emilsson, V., Meddens, S.F., Oskarsson, S., Pickrell, J.K., Thom, K., Timshel, P., de Vlaming, R., Abdellaoui, A., Ahluwalia, T.S., Bacelis, J., Baumbach, C., Bjornsdottir, G., Brandsma, J.H., Pina Concas, M., Derringer, J., Furlotte, N.A., Galesloot, T.E., Girotto, G., Gupta, R., Hall, L.M., Harris, S.E., Hofer, E., Horikoshi, M., Huffman, J.E., Kaasik, K., Kalafati, I.P., Karlsson, R., Kong, A., Lahti, J., van der Lee, S.J., de Leeuw, C., Lind, P.A., Lindgren, K.O., Liu, T., Mangino, M., Marten, J., Mihailov, E., Miller, M.B., van der Most, P.J., Oldmeadow, C., Payton, A., Pervjakova, N., Peyrot, W.J., Qian, Y., Raitakari, O., Rueedi, R., Salvi, E., Schmidt, B., Schraut, K.E., Shi, J., Smith, A.V., Poot, R.A., St Pourcain. B,, Teumer, A., Thorleifsson, G., Verweij, N., Vuckovic, D., Wellmann, J., Westra, H.J., Yang, J., Zhao, W., Zhu, Z., Alizadeh, B.Z., Amin, N., Bakshi, A., Baumeister, S.E., Biino, G., Bønnelykke, K., Boyle, P.A., Campbell, H., Cappuccio, F.P., Davies, G., De Neve, J.E., Deloukas, P., Demuth, I., Ding, J., Eibich, P., Eisele, L., Eklund, N., Evans, D.M., Faul, J.D., Feitosa, M.F., Forstner, A.J., Gandin, I., Gunnarsson, B., Halldórsson, B.V., Harris, T.B., Heath, A.C., Hocking, L.J., Holliday, E.G., Homuth, G., Horan, M.A., Hottenga, J.J., de Jager, P.L., Joshi, P.K., Jugessur, A., Kaakinen, M.A., Kähönen, M., Kanoni, S., Keltigangas-Järvinen, L., Kiemeney, L.A., Kolcic, I., Koskinen, S., Kraja, A.T., Kroh, M., Kutalik, Z., Latvala, A., Launer, L.J., Lebreton, M.P., Levinson, D.F., Lichtenstein, P., Lichtner, P., Liewald, D.C.; LifeLines Cohort Study, Loukola, A., Madden, P.A., Mägi, R., Mäki-Opas, T., Marioni, R.E., Marques-Vidal, P., Meddens, G.A., McMahon, G., Meisinger, C., Meitinger, T., Milaneschi, Y., Milani, L., Montgomery, G.W., Myhre, R., Nelson, C.P., Nyholt, D.R., Ollier, W.E., Palotie, A., Paternoster, L., Pedersen, N.L., Petrovic, K.E., Porteous, D.J., Räikkönen, K., Ring, S.M., Robino, A., Rostapshova, O., Rudan, I., Rustichini, A., Salomaa, V., Sanders, A.R., Sarin, A.P., Schmidt, H., Scott, R.J., Smith, B.H., Smith, J.A., Staessen, J.A., Steinhagen-Thiessen, E., Strauch, K., Terracciano, A., Tobin, M.D., Ulivi, S., Vaccargiu, S., Quaye, L., van Rooij, F.J., Venturini, C., Vinkhuyzen, A.A., Völker, U., Völzke, H., Vonk, J.M., Vozzi, D., Waage, J., Ware, E.B., Willemsen, G., Attia, J.R., Bennett, D.A., Berger, K., Bertram, L., Bisgaard, H., Boomsma, D.I., Borecki, I.B., Bültmann, U., Chabris, C.F., Cucca, F., Cusi, D., Deary, I.J., Dedoussis, G.V., van Duijn, C.M., Eriksson, J.G., Franke, B., Franke, L., Gasparini, P., Gejman, P.V., Gieger, C., Grabe, H.J., Gratten, J., Groenen, P.J., Gudnason, V., van der Harst, P., Hayward, C., Hinds, D.A., Hoffmann, W., Hyppönen, E., Iacono, W.G., Jacobsson, B., Järvelin, M.R., Jöckel, K.H., Kaprio, J., Kardia, S.L., Lehtimäki, T., Lehrer, S.F., Magnusson, P.K., Martin, N.G., McGue, M., Metspalu, A., Pendleton, N., Penninx, B.W., Perola, M., Pirastu, N., Pirastu, M., Polasek, O., Posthuma, D., Power, C., Province, M.A., Samani, N.J., Schlessinger, D., Schmidt, R., Sørensen, T.I., Spector, T.D., Stefansson, K., Thorsteinsdottir, U., Thurik, A.R., Timpson, N.J., Tiemeier, H., Tung, J.Y., Uitterlinden, A.G., Vitart, V., Vollenweider, P., Weir, D.R., Wilson, J.F., Wright, A.F., Conley, D.C., Krueger, R.F., Davey Smith, G., Hofman, A., Laibson, D.I., Medland, S.E., Meyer, M.N., Yang, J., Johannesson, M., Visscher, P.M., Esko, T., Koellinger, P.D., Cesarini, D., Benjamin, D.J. Genome-wide association study identifies 74 loci associated with educational attainment. Nature 533(7604) (2016) 539-542.
  22. Mayer, O., Seidlerová, J., Wohlfahrt, P., Filipovský, J., Vaněk, J., Cífková, R., Windrichová, J., Topolčan, O., Knapen, M.H.J., Drummen, N.E.A., Vermeer, C. Desphospho-uncarboxylated Matrix Gla-Protein is associated with increased aortic stiffness in a general population. J. Hum. Hypertens. 30 (2016) 418-423..
  23. Lu, Y.C., Li, S.S., Zhang, H.F., Odili, A.N., Yao, W.M., Gong, L., Zhou, Y.L., Zhou, F., Yang, R., Sheng, Y.H., Xu, D.J., Kong, X.Q., Staessen, J.A., Li, X.L. Quality control of the blood pressure phenotype in the Gaoyou population study. Blood Press. 25 (2016) 162.168.
  24. Van Leeuw, J.B., Berra, E., Gu, Y., Petit, T., Lacroix, V., Lanthier, N., Van Hoof, M., Staessen, J.A., Persu, A. Alpha-1 antitrypsin deficiency: a novel cause of isolated systolic resistant hypertension? J. Hypertens. 34 (2016) 1659-1661.
  25. Wei, F.F., Zhang, Z.Y., Thijs, L., Yang, W.Y., Jacobs, L., Cauwenberghs, N., Gu, Y.M., Kuznetsova, T., Allegaert, K., Verhamme, P., Li, Y., Struijker-Boudier, H.A., Staessen, J.A. Conventional and ambulatory blood pressure as predictors of retinal arteriolar narrowing. Hypertension 68 (2016) 511-520..
  26. Berra, E., Azizi, M., Capron, A., Høieggen, A., Rabbia, F., Kjeldsen, S.E., Staessen, J.A., Wallemacq, P., Persu, A. Evaluation of adherence should become an integral part of assessment of patients with apparently treatment-resistant hypertension. Hypertension 68 (2016) 297-306.
  27. Ntineri A, Stergiou GS, Thijs L, Asayama K, Boggia J, Boubouchairopoulou N, Hozawa A, Imai Y, Johansson JK, Jula AM, Kollias A, Luzardo L, Niiranen TJ, Nomura K, Ohkubo T, Tsuji I, Tzourio C, Wei FF, Staessen JA. Relationship between office and home blood pressure with increasing age: The International Database of HOme blood pressure in relation to Cardiovascular Outcome (IDHOCO). Hypertens Res. 39 (2016) 612-617.
  28. Wei, F.-F. Drummen, N.E.A., Thijs, L., Jacobs, L., Herfs, M., van `t Hoofd, C., Vermeer, C.,. Staessen, J.A. Vitamin K dependent protection of the renal microvasculature: histopathological studies in normal and diseased kidneys. Pulse 4 (2016) 85-91.
  29. Vermeer, C. Vitamin K and capillary function. International patent nr. WO 2016/131993 A2. Publication date: Aug 25, 2016
  30. Vermeer, C. Drummen, N.E.A., Knapen, M.H.J., Zandbergen, F. Uncarboxylated matrix Gla protein as a biomarker in cardiovascular disease: applications for research and for routine diagnostics. In: Biomarkers in Cardiovascular Disease (Patel, V.B. and Preedy, V.R., Eds.) 2016, 267-283. Springer Netherlands ISBN: 978-94-007-7741-5. DOI: 10.1007/978-94-007-7741-5_14-1, pp267-283.
  31. Shea, M.K., Loeser, R.F., Hsu, F.-C., Booth, S.L., Nevitt, M., Simonsick, E.M., Strotmeyer, E.S., Vermeer, C., Kritchevsky, S.B.Vitamin K Status and Lower Extremity Function in Older Adults: The Health Aging and Body Composition Study.J. Gerontol. Med. Sci. 71 (2016) 1348-1355.
  32. Knapen, M.H.J., Braam, L.A.J.L.M, Teunissen, K.J., Van’t Hoofd, C.M., Zwijsen, R.M., van den Heuvel E.G., Vermeer, C. Steady-state vitamin K2 (menaquinone-7) plasma concentrations after intake of dairy products and soft gel capsules. Eur. J. Clin. Nutr. 70 (2016) 831-836.

Papers, in press:

  1. Zwakenberg, S.R., Engelen, A.I.P., Dalmeijer, G.W., Booth, S.L., Vermeer, C., Drijvers, J., Ocke, M.C., Feskens, E.J.M., van der Schouw, Y.T., Beulens, J.W.J. Reproducibility and relative validity of a food frequency questionnaire to estimate intake of dietary phylloquinone and menaquinones. Eur. J. Nutr.
  2. Jin, D.-Y., Vermeer, C., Stafford, D.W., Tie, J.-K. Splice-site mutation of exon 3 deletion in gamma-glutamyl carboxylase gene causes inactivation of the enzyme. J. Invest. Dermatol.
  3. Pontillo, C., Jacobs, L., Staessen, J.A., Schanstra, J.P., Rossing, P., Heerspink, H.J., Siwy, J., Mullen, W., Vlahou, A., Mischak, H., Vanholder, R., Zürbig, P., Jankowski, J. A urinary proteome-based classifier for the early detection of decline in glomerular filtration. Nephrol Dial Transplant. 2016
  4. Zwakenberg, S.R., den Braver, N.R., Engelen, A., Feskens, E.J.M., Vermeer, C., Boer, J.M.A., Verschuren, W.M.M., van der Schouw, Y.T., Beulens, J.W.J. Vitamin K intake and all-cause and cause specific mortality. Clin. Nutr.
  5. Wei, F.F., Zhang, Z.Y., Petit, T., Cauwenberghs, N., Gu, Y.M., Thijs, L., Raaijmakers, A., Jacobs, L., Yang, W.Y., Allegaert, K., Kuznetsova, T., Verhamme, P., Struijker-Boudier, H.A., Li, Y., Asayama, K., Staessen, J.A. Retinal microvascular diameter, a hypertension-related trait, in ECG-gated vs. non-gated images analyzed by IVAN and SIVA. Hypertens Res. 2016 .
  6. Mayer, O., Seidlerová, J., Wohlfahrt, P., Filipovský, J., Cifkova, R., Cerna, V., Kucerova, A., Pesta, M., Fuchsova, R., Topolcan, O., Jardon, K.M.C., Drummen, N.E.A., Vermeer, C. Synergistic effect of low K and D vitamin status on arterial stiffness in a general population. J. Nutr. Biochem..
Publication list 2015 of Associate Professor Dr. Cees Vermeer
  1. Mayer, O., Seidlerová, J., Bruthans, J., Filipovský, J., Timoracká, K., Vaněk, J., Černá, L., Wohlfahrt, P., Cífková, R., Knapen, M.H.J., Drummen, N.E.A., Vermeer, C. The association between uncarboxylated matrix Gla protein and lipoprotein associated phospholipase A2. Maturitas 80 (2015) 82-88.
  2. Hara, A., Thijs, L., Asayama, K., Gu, Y.-M., Jacobs, L., Zhang, Z.-Y., Liu, Y.P.,Nawrot, T.S., Staessen, J.A. Blood pressure in relation to environmental lead exposure in the national health and nutrition examination survey 2003–2010. Hypertension 65 (2015) 62-69.
  3. Zhang, Z., Thijs, L., Staessen, J.A. Left ventricular mass in relation to midlife blood pressure. Eur. Heart J. 35 (2014) 3242-3244.
  4. Franklin, S.S., O’Brien, E., Thijs, L., Asayama, K., Staessen, J.A. Masked hypertension: a phenomenon of measurement. Hypertension 65 (2015) 16-20.
  5. Liu, Y-P., Gu, Y.-M., Thijs, L., Knapen, M.H.J., Salvi, E., Citterio, L., Petit, T., Delli Carpini, S., Zhang, Z.-Y., Jacobs, L., Jin, Y.L., Barlassina, C., Manunta, P., Kuznetsova, T., Verhamme, P., Struijker-Boudier, H.A., Cusi, D., Vermeer, C., Staessen, J.A. Inactive Matrix Gla Protein is causally related to health outcomes: a Mendelian randomization study in a Flemish population. Hypertension 65 (2015) 463-470.
  6. Viegas, C., Willems, B., Vermeer, C., Simes, D. Gla-rich protein (GRP) acts as a calcification inhibitor in the human cardiovascular system. Atheroscl. Thromb. Vasc. Biol. 35 (2015) 399-408.
  7. Asayama, K., Wei, F.F., Liu, Y.P., Hara, A., Gu, Y.M., Schutte, R., Li, Y., Thijs, L., Staessen, J.A. Does blood pressure variability contribute to risk stratification? Methodological issues and a review of outcome studies based on home blood pressure. Hypertens. Res. . 38 (2015) 97-101.
  8. Keyzer, C.A., Vermeer, C., Joosten, M., Knapen, M.H.J., Drummen, N.E.A., Navis, G., Bakker, S.J.L., De Borst, M.H. Vitamin K status and outcomes after kidney transplantation. Am. J. Kidney Dis. 65 (2015) 474-483.
  9. Shea, M.K., Kritchevsky, S.B., Hsu, F.-C., Nevitt, M., Booth, S.L., Kwoh, C.K., McAlindon, T.E., Drummen, N.E.A., Vermeer, C., Harris, T.B., Martin, K., Womack, C., Loeser, R.F. The association between vitamin K status and knee osteoarthritis features in older adults: the Healthy Aging and Body Composition Study. Osteoarthritis and Cartilage 23 (2015) 370-378.
  10. Fadl Elmula, F.E., Larstorp, A.C., Kjeldsen, S.E., Persu, A., Jin, Y., Staessen, J.A. Renal sympathetic denervation after Symplicity HTN-3 and therapeutic drug monitoring in severe hypertension. Front Physiol. 2015 Feb 9;6:9. doi: 10.3389/fphys.2015.00009.
  11. Gu, Y.M., Staessen, J.A. Dynamic interaction between micro- and macro-circulation: a concept with feet of clay. Am. J. Hypertens.. 28 (2015) 693-6944.
  12. Knapen, M.H.J., Braam, L.A.J.L.M., Drummen, N.E.A., Bekers, O., Hoeks, A.P.G., Vermeer, C. Low-dose menaquinone-7 supplementation improves vascular properties in healthy postmenopausal women. Thromb. Haemostas. 113 (2015) 1135-1144.
  13. Gu, Y.-M., Wang, S., Zhang, L., Liu, Y.-P., Thijs, L., Petit, T., Zhang, Z., Wei, F.-F., Kang, Y.-Y., Huang, Q.-F., Sheng, C.-S., Struijker-Boudier, H.A.J., Kuznetsova, T., Verhamme, P., Li, Y., Staessen, J.A. Characteristics and determinants of the sublingual microcirculation in populations of different ethnicity. Hypertension 65 (2015) 993-1001.
  14. Persu, A., Jin, Y., Fadl Elmula, F.E., Renkin, J., Høieggen, A., Kjeldsen, S.E., Staessen, J.A. Renal denervation in treatment-resistant hypertension: a reappraisal. Curr. Opin. Pharmacol. 21 (2015) 48-52.
  15. Zhang, L., Li, Y., Wei, F.F., Thijs, L., Kang, Y.Y., Wang, S., Xu, T.Y., Wang, J.G., Staessen, J.A. Strategies for classifying patients based on office, home, and ambulatory blood pressure measurement. Hypertension 65 (2015) 1258-1265.
  16. Asayama, K., Wei, F.F., Hara, A., Hansen, T.W., Li, Y., Staessen, J.A. Prognosis in relation to blood pressure variability: con side of the argument. Hypertension 65 (2015) 1170-1179.
  17. Pivin, E., Ponte, B., Pruijm, M., Ackermann, D., Guessous, I., Ehret, G., Liu, Y.-P., Drummen, N., Knapen, M., Pechère-Bertschi, A., Paccaud, F., Mohaupt, M., Vermeer, C., Staessen, J., Vogt, B., Martin, P.-Y., Burnier, M., Bochud, M. Inactive matrix GLA protein is associated with arterial stiffness. Hypertension 66 (2015) 85-92.
  18. Dam, V., Dalmeijer, G.W., Vermeer C., Drummen, N.E.A., Knapen, M.H.J., van der Schouw, Y.T., Beulens, J.W. The association between vitamin K and the metabolic syndrome: a 10 year follow-up study in adults. J. Clin. Endocrinol. Metab. Epub..100 (2015) 2472-2479.
  19. Zhang, Z.Y., Thijs, L., Petit, T., Gu, Y.M., Jacobs, L., Yang, W.Y., Liu, Y.P., Koeck, T., Zürbig, P., Jin, Y., Verhamme, P., Voigt, J.U., Kuznetsova, T., Mischak, H., Staessen, J.A. Urinary proteome and systolic blood pressure as predictors of 5-year cardiovascular and cardiac outcomes in a general population. Hypertension 66 (2015) 52-60.
  20. Niiranen, T.J., Asayama, K., Thijs, L., Johansson, J.K., Hara, A., Hozawa, A., Tsuji, I., Ohkubo, T., Jula, A.M., Imai, Y., Staessen, J.A. Optimal number of days for home blood pressure measurement. Am. J. Hypertens. 28 (2015) 595-603.
  21. Meeuwese, C.L., Olauson, H., Qureshi, A.R., Ripszweden, J., Barany, P., Vermeer, C., Drummen, N.E.A., Stenvinkel, P. Associations between thyroid hormones, calcification inhibitor levels and vascular calcification in end-stage renal disease. PLOS ONE | DOI:10.1371/journal.pone.0132353 July 6, 2015.
  22. Meuwese, C.L., Olauson, H., Qureshi, A.R., Ripszweden, J., Barany, P., Vermeer, C., Drummen, N.E.A., Stenvinkel, P. Associations between thyroid hormones, calcification inhibitor levels and vascular calcification in end-stage renal disease. PLOS ONE 10 (2015) e132353| DOI:10.1371/journal.pone.0132353
  23. Pivin, E., Pruijm, M., Ackermann, D., Guessous, I., Ehret, G., Pechère-Bertschi, A., Paccaud, F., Mohaupt, M., Vermeer, C., Staessen, J.A., Vogt, B., Martin, P., Burnier, M., Bochud, M., Ponte, B. Inactive Matrix Gla Protein is associated with renal resistive index in a population-based study.J. Hypertens.. 33 (2015) Suppl 1:e15.
  24. Aparicio, L.S., Thijs, L., Boggia, J., Jacobs, L., Barochiner, J., Odili, A.N., Alfie, J., Asayama, K., Cuffaro, P.E., Nomura, K., Ohkubo, T., Tsuji, I., Stergiou, G.S., Kikuya, M., Imai, Y., Waisman, G.D., Staessen, J.A. Defining Thresholds for Home Blood Pressure Monitoring in Octogenarians. Hypertension 66 (2015) 865-873.
  25. Kurnatowska, I., Grzelak, P., Masajtis-Zagajewska, A., Kaczmarska, M., Stefańczyk, L., Vermeer, C., Maresz, K., Nowicki, M. Effect of vitamin K2 on progression of atherosclerosis and vascular calcification in non-dialyzed patients with chronic kidney disease stage 3-5. Pol Arch Int. Med. 125 (2015) 631-640.
  26. Yang, W.Y., Petit, T., Thijs, L., Zhang, Z.Y., Jacobs, L., Hara, A., Wei, F.F., Salvi, E., Citterio, L., Delli Carpini, S., Gu, Y.M., Knez, J., Cauwenberghs, N., Barcella, M., Barlassina, C., Manunta, P., Coppiello. G., Aranguren, X.L., Kuznetsova, T., Cusi, D., Verhamme, P., Luttun, A., Staessen, J.A. Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population. BMC Genet. 16 (2015):116. doi: 10.1186/s12863-015-0272-2.
  27. Winkler TW, Justice AE, Graff M, et al. The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet. 11 (2015):e1005378. doi: 10.1371/journal.pgen.1005378.
  28. Knapen, M.H.J., Braam, L.A.J.L.M., Teunissen, K.T., R.M.L. Zwijsen, R.M.L., Theuwissen, E., Vermeer, C.Yogurt drink fortified with menaquinone-7 improves vitamin K status in a healthy population. J. Nutr. Scie. 4 (2015) e35, 1 – 8
  29. Van den Heuvel, E.G.H.M., van Schoor, N.M., Vermeer, C., Zwijsen, R., Theuwissen, E., den Heijer, M., Comijs, H.C. Vascular vitamin K status is not associated with a decline in cognitive performance in relatively healthy adults.. J. Nutr. Health & Aging 19 (2015) 908-912.
  30. Vossen, L.M., Schurgers, L.J., van Varik, B.J., Kietselaer, B.L.J.H., Vermeer, C., Meeder, J.G., Rahel, B.M., van Cauteren, Y.J.M., Hoffland, Rennenberg, R.J.M.W., Reesink, K.D., de Leeuw, P.W., Kroon. A.A. Menaquinone-7 supplementation to reduce vascular calcification in patients with coronary artery disease: rationale and study protocol (VitaK-CAC trial). Nutrients 7 (2015) 8905-8915.
  31. Altara, R., Gu, Y.M., Struijker-Boudier, H.A., Thijs, L., Staessen, J.A., Blankesteijn, W.M. Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study. PLoS One. 2015 Oct 27;10(10):e0141394.
  32. Wei, F.F., Drummen, N.A.E., Thijs, L., Jacobs, L., Knapen, M.H.J., Petit, T., Yang, W.Y., Zhang, Z.Y., Gu, Y.M., Kuznetsova, T., Verhamme, P., Evenepoel, P., Vermeer, C. Staessen, J.A.. Inhibition of arterial calcification by matrix Gla protein as determinant of renal function in the general population. Artery Res. 12 (2015) 16.
  33. Petit, T., Zhang, Z.Y., Yang, W.Y., Wei, F.F., Gu, Y.M., Knez, J., Cauwenberghs, N., Liu, Y.P., Drummen, N.A.E., Jacobs L., Thijs, L., Kuznetsova, T., Janssens, S., Vermeer, C., Staessen, J.A. Matrix Gla Protein in relation to left ventricular diastolic function. Artery Res. 12 (2015) 46.
  34. Garcia Segarra, N., Ballhausen, D., Crawford, H., Perreau, M. , Campos-Xavier, B., van Spaendonck-Zwarts, K., Vermeer, C., Russo, M., Zambelli, P.-Y., Stevenson, B., Bertrand, B.-R., Rivolta, C., Candotti, F., Unger, S., Munier, F., Superti-Furga, A., Bonafé, L. NBAS mutations cause a multisystem disorder involving bone, connective tissue, liver, immune system and retina. Am. J. Med. Genet. – A 167 (2015) 2902-2912.
  35. Hosaka, M., Asayama, K., Staessen, J.A., Tatsuta, N., Satoh, M., Kikuya, M., Ohkubo, T., Satoh, H., Imai, Y., Nakai, K. Relationship between maternal gestational hypertension and home blood pressure in 7-year-old children and their mothers: Tohoku Study of Child Development. Hypertens. Res. 38 (2015) 1170-1179.
Publication list 2014 of Associate Professor Dr. Cees Vermeer
  1. Theuwissen, E., Magdeleyns, E.J., Braam, L.A.J.L.M., Teunissen, K.J., Knapen, M.H.J., Binnekamp, I.A.G., van Summeren, M.J.H., Vermeer, C. Vitamin K status in healthy volunteers. Food & Funct. 5 (2014) 229-234.
  2. Van den Heuvel, E.G.H.M., van Schoor, N.M., Lips, P., Magdeleyns, E.J.P., Deeg, D.J.H., Vermeer, C., Heijer, M.D. Circulating uncarboxylated Matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease.Maturitas 77 (2014) 137-141.
  3. Rødbotten, R., Gundersen, T., Vermeer, C., Berg, J., Kirkhus, B. Vitamin K2 in meat from steers of Jersey and Norwegian Red. Meat Science 97 (2014) 49-53.
  4. Liabeuf, S., Olivier, B., Vemeer, C, Theuwissen, E., Magdeleyns, E.J.P., Aubert, C.E., Brazier, M., Mentaverri, M., Hartemann, A., Massy, Z.A. Vascular calcification in Type 2 diabetic patients: the involvement of Matrix Gla protein. Cardiovasc. Diabetol. 13:85 (2014) 1-8.
  5. Knapen, M.H.J., Theuwissen, E., Braam, L.A.J.L.M., Vermeer, C. Pharmacokinetics of menaquinone-7 (vitamin K2) in healthy volunteers. J. Clin. Trials 4 (2014) 160. doi:10.4172/2167-0870.1000160
  6. Mayer, O., Mlíková-Seidlerová, J., Bruthans, J., Filipovský, J., Timoracká, K., Vaněk, J., Černá, L., Wohlfahrt, P., C., Renata, Theuwissen, E., Vermeer, C.. Desphospho-uncarboxylated matrix Gla protein is associated with mortality risk in patients with chronic stable vascular disease.Atherosclerosis 235 (2014) 162-168.
  7. Viegas, C.S.B., Herfs, M., Rafael, M.S., Enriquez, J.L., Teixeira, A., Luis, I.M., van ‘t Hoofd, C.M.R., João, A., Maria, V.L., Cavaco, S. Ferreira, A., Serra, M., Theuwissen, E., Vermeer, C., Simes, D.C. Gla-Rich Protein Is a Potential New Vitamin K Target in Cancer: Evidences for a Direct GRP-Mineral Interaction. BioMed Res.Int. 340216 (2014). doi:10.1155/2014/340216.
  8. Schurgers, L.J., Joosen, I.A., Laufer, E.M., Chatrou, M.L.L., Herfs, M., Winkens, M.H.M., Westenfeld, R., Veulemans, V., Krueger, T., Shanahan, C.M., Jahnen-Dechent, W., Biessen, E., Narula, J., Vermeer, C, Hofstra, L., Reutelingsperger, C.P. Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype. PLoS ONE 7(2014): e43229. doi:10.1371/journal.pone.0043229
  9. Dalmeijer, G.W., van der Schouw, Y.T., Magdeleyns, E.J., Vermeer, C., Verschuren, W.M.M., Boer, J.M.A., Beulens, J.W.J.Circulating desphospho-uncarboxylated matrix Gla protein and the risk of coronary heart disease and stroke. J. Thromb. Haemostas, 12 (2014) 1028-1034.
  10. Caluwé, R., Vandecasteele, S., Van Vlem, B., Vermeer, De Vriese, A.S. Vitamin K2 supplementation in hemodialysis patients: a randomized dose-finding study. Nephrol. Dial. Transpl. 29 (2014) 1385-1390.
  11. Kaesler, N., Magdeleyns, E., Herfs, M., Schettgen, T., Brandenburg, V., Fliser, D., Vermeer, C., Floege, J., Schlieper, G. Krüger, T. Impaired vitamin K recycling in uremia is rescued by vitamin K supplementation. Kidney Int. 86 (2014) 286-293.
  12. Willems, B.A.G., Vermeer, C., Reutelingsperger, C.P.M., Schurgers, L.J. The realm of vitamin K-dependent proteins: shifting from coagulation towards calcification.Mol. Nutr. Food Res. 58 (2014) 1620-1635.
  13. Mayer, O., Seidlerova, J., Filipovsky, J., Vermeer, C. The association between circulating undercarboxylated Matrix Gla-Proteinand arterial stiffness in general population. Artery Res. 8 (2014) 122.
  14. Liu, Y.-P., Gu, Y.-M., Thijs, L., Knapen, M., Salvi, E., Citterio, L., Petit, T., Carpini, S., Zhang, Z.-Y., Jacobs, L., Jin, Y., Barlassina, C., Manunta, P., Kuznetsova, T., Verhamme, P., Struijker-Boudier, H., Cusi, D., Vermeer, C. Staessen, J. Inactive Matrix Gla Protein is causally related to health outcomes: a Mendelian randomization study in Flemish population. Artery Res. 8 (2014) 125.
  15. Rafael, M.S., Cavaco, S., Viegas, C.S.B., Santos, S., Ramos, A., Willems, B., Herfs, M., Theuwissen, E., Vermeer, C., Simes, D.C. Insights into the association of Gla-rich protein (GRP) and osteoarthritis: novel splice variants and g-carboxylation status. Mol. Nutr. Food Res. 58 (2014) 1636-1646.
  16. Mark, P.B.,Schiffrin, E.L., Jennings, G.L., Dominiczak, A.F., Wang, L.-G., De Buyzere, M., Staessen, J.A. Renovascular Hypertension To Stent or Not to Stent? Hypertension 64 (2014) 1165-1168.
  17. Zhang, Z., Thijs, L., Staessen, J.A. Left ventricular mass in relation to midlife blood pressure. Eur. Heart J. 35 (2014) 3242-3244.
Publication list 2013 of Associate Professor Dr. Cees Vermeer
  1. Dalmeijer, G.W., van der Schouw, Y.T., Vermeer, C., Magdeleyns, E.J., Schurgers, L.J., Beulens, J.W.J. Circulating matrix Gla protein is associated with coronary artery calcification and vitamin K status in healthy women. J. Nutr. Biochem. 24 (2013) 624-628.
  2. Boraldi, F., Annovi, G., Vermeer, C., Schurgers, L.J., Trenti, T., Tiozzo, R., Guerra, D., Quaglino, D. Matrix Gla Protein and alkaline phosphatase are differently modulated in human dermal fibroblasts of PXE patients and controls. J. Invest. Dermatol. 133 (2013) 946-954.
  3. Theuwissen, E., Teunissen, K.J. Spronk, H.M., Hamulyák, K., Ten Cate, H., Shearer, M.J., Vermeer, C., Schurgers, LJ. Effect of low-dose vitamin K2 intake on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers. J. Thromb. Haemostas. 11 (2013) 1085-1092.
  4. Engelen, L., Ferreira, I., Stehouwer, C.D., Boutouyrie, P., Laurent, S., Boutouyrie, P., Laurent, S., Jouven, X., Empana, J.P., Bozec, E., Simon, T., Pannier, B., Mattace-Raso, F.U., Hofman, A., Franco, O.H., Kavousi, M., van Rooij, F.J., Witteman, J., Riezschel, E., Vermeersch, S., Segers, P., Van Bortel, L., De Bacquer, D., Van Daele, C., De Buyzere, M., Bots, M.L., van der Schouw, Y.T., Grobbee, D.E., Uiterwaal, C.S., Evelein, A., van der Graaf, Y., Visseren, F.L., Stehouwer, C., Fewrreira, I., Dekker, J., Nijpels, G., Twisk, J., Smulders, Y., Schalkwijk, C., van Greevenbroek, M., van der Kallen, C., van de Laar, R., Feskens, E., Staessen, J., Thijs, L., Kouznetsova, T., Jin, Y, Liu, Y., Benetos, A., Labat, C., Lacolley, P., Wang, J., Li, Y., Fischer, J., Terris, D., Jarczok, M., Thole, M., Heuten, H., Govaerts, I., Ennekens, G., Vrints, C., Ryliskyte, L. Laucevicius, A., Ryliskiene, K., Kuzmickiene, J., Bianchini, E., Ghiadoni, L., Bruno, R.M., Cartoni, G., Taddei, S., Tolezani, E.C., Hong, V., Bortolotto, H., Vermeer, C., Braam, L., Knapen, M., Drummen, N., Rimoldi, S.F., Stucki, F., Hutter, D., Rexhaj, E., Faita, F., Sartoni, C., Scherrer, U., Allemann, Y., Delahousse, M., Karras, A., Giannettasio, C., Cesana, F., Nava, S., Maloberti, A., Kollai, M., Pintér, A., Horváth, T., Narkiewicz, K., Szyndler, A., Hoffmann, M., Nowak, R., Polonis, K., Thuillez, C., Joannidès, R., Bellien, J., Angel, K., Atar, D., Filipovsky, J., Agharazii, M., Briet, M. Reference intervals for common carotid intima-media thickness measured with echotracking – relation with risk factors. Eur. Heart J., 34 (2013) 2368-2380.
  5. Knapen, M.H.J., Drummen, N.E., Smit, E., Vermeer, C., Theuwissen, E. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos. Int. 24 (2013) 2499-2507.
  6. Crăciun, A.M., Vermeer, C. Apolipoprotein E genotype may influence urinary gammacarboxyglutamate (Gla) concentrations in young individuals. Gen. Physiol. Biophys. 32 (2013) 303-310.
  7. Boraldi, F., Garcia-Fernandez, M.I., Paolinelli-deVincenzi, C., Annovi, G., Schurgers, L., Vermeer, C., Cianciulli, P., Ronchetti, I., Quaglino, D. Ectopic calcifications in beta-thalassemia patients are associated to increased oxidative stress and lower MGP carboxylation. BBA – Molecular Basis of Disease 1832 (2013) 2077-2084.
  8. Beulens, J.W.J., Booth, S.L., van den Heuvel, E., Stoecklin, E., Vermeer, C. The role of menaquinones (vitamin K2) in human health. Brit. J. Nutr. 110 (2013) 1357-1368.
  9. Krüger, T., Oelenberg, S., Schurgers, L., van de Sandt, A., Boor, P., Schlieper, G.R., Brandenburg, V., Fekete, B.C., Veulemans, V., Schafer, C., Ketteler, M., Merx, M.W., Vermeer, C., Jahnen-Dechent, W., Floege, J., Westenfeld, R. Warfarin induces cardiovascular damage in mice. Arterioscler. Thromb. Vasc. Biol. 33 (2013) 2618-2624.
  10. Dalmeijer, G.W., van der Schouw, Y.T., Vermeer, C., Magdeleyns, E.,Velthuis, B.K., de Jong, P.A., Elias, S.G., Beulens, J.W.J. Circulating species of matrix Gla protein and the risk of vascular calcification in healthy women. Int. J. Cardiol 169 (2013) e168-e170.
  11. Dalmeijer, G.W., van der Schouw, Y.T., Magdeleyns, E., Vermeer, C., Verschuren, W.M.M., de Boer, J.M.A., Beulens, J.W.J. Matrix Gla Protein species and risk of cardiovascular events in type 2 diabetes patients. Diabetes Care 36 (2013) 3766-3771.
  12. Theuwissen, E., Badmaev, V., Vermeer, C. Calcium intake and cardiovascular disease mortality: is there a critical role for vitamin K? JAMA Internal Medicine 173 (2013) 1841.
  13. Qureshi, T.M., Vermeer, C., Vegarud, G.E., Abrahamsen, R.K., Skeie, S. Biogenic amines and vitamin K contents in the Norwegian autochthonous cheese Gamalost during ripening. Dairy Sci. & Technol. 93 (2013) 303-314.
  14. Caluwé, R., Vandecasteele, S., Van Vlem, B., Vermeer, De Vriese, A. Vitamin K2 supplementation in hemodialysis patients: a randomized dosefinding study. Nephrol. Dial. Transpl. epub
  15. Van den Heuvel, E.G.H.M., van Schoor, N.M., Deeg, D.J.H., Vermeer, C., Magdeleyns, E.J.P., Lips, P., den Heijer, M. Circulating uncarboxylated Matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease. Maturitas epub
  16. Theuwissen, E., Magdeleyns, E.J., Braam, L.A.J.L.M., Teunissen, K.J., Knapen, M.H.J., Binnekamp, I.A.G., van Summeren, M.J.H., Vermeer, C. Vitamin K status in healthy volunteers. Food Funct. epubPublished patents:– Quinlan, P.T., Vermeer. C. Vitamin containing product. US Patent No. 8 354 129. Jan 15, 2013.– Vermeer C. Use of vitamin K for weight maintenance and weight control. US patent No 2013-0267606-A1. Oct 10, 2013.– Vermeer, C., de Borst, M. Use of vitamin K to decrease allograft failure and patient mortality after organ transplantation. WO2013/182578-A1. Dec 12, 2013.– Vermeer, C., de Borst, M. New biomarkers to estimate the risk of allograft failure and patient mortality after organ transplantation. WO 2013/182579-A1. Dec 12, 2013.
Publication list 2012 of Associate Professor Dr. Cees Vermeer
  1. Westenfeld, R., Krueger, T., Schlieper, G., Cranenburg, E.C.M., Magdeleyns, E.J., Heidenreich, S., Holzmann, S., Vermeer, C. Jahnen-Dechent, W., Ketteler, M., Floege, J., Schurgers, L.J. Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial . Am. J. Kidney Dis. 59 (2012) 186-195.
  2. Theuwissen. E., Smit, E., Vermeer, C. The role of vitamin K in soft tissue calcification. Adv. Nutr. 3 (2012) 166-173.
  3. Vermeer, C. Vitamin K: the effect on health beyond coagulation. Food Nutr. Res. 56 (2012) 5329.
  4. Vermeer, C., Knapen, M.H.J. Vitamin K and bone health. In: Diet, nutrients and bone health. Ed.: Anderson, J.B.J., Garner, S.C., Klemmer, P.J. CRC Press 2012, pp 193-212. ISBN: 978-1-4398-1855-5.
  5. Cranenburg, E.C.M., Schurgers, L.J., Uiterwijk, H., Beulens, J., Dalmeijer, G., Westerhuis, R., Magdeleyns, E.J., Herfs, M., Vermeer, C. Laverman, G. Vitamin K intake and status are low in hemodialysis patients. Kidney Int. 82 (2012) 605-610.
  6. Schurgers, L.J., Joosen, I.A., Laufer, E.M., Chatrou, M., Herfs, M., Westenfeld, R., Veulemans, V., Shanahan, C.M., Jahnen-Dechent, W., Biessen, E., Narula, J., Vermeer, C., Hofstra, L., Reutelingsperger, C.P. Vitamin K-antagonists accelerate intimal plaque calcification and induce a vulnerable plaque phenotype. PLoS One7(8): e43229. doi:10.1371/journal.pone.0043229.
  7. Knapen, M.H.J., Schurgers, L.J., Shearer, M.J., Newman, P., Theuwissen, E., Vermeer, C. Uncarboxylated osteocalcin is not associated with fat mass and body weight in healthy subjects. Brit. J. Nutr. 108 (2012) 1017-1024.
  8. Theuwissen, E., Vermeer, C., Smit, E. Health benefits of vitamin K2 are presently underestimated. Nutracos 11 Vitamins Supplement (2012) 2-6.
  9. Boxma, P.Y., van den Berg. E, Geleijnse, J.M., Laverman, G.D., Schurgers, L.J, Vermeer, C., Kema, I.P., Muskiet, F.A., Navis, G., Bakken, S.J.L., de Borst, M.H. Vitamin K Intake and Plasma Desphospho-Uncarboxylated Matrix Gla-Protein Levels in Kidney Transplant Recipients. PLoS ONE 7(2012): e47991. doi:10.1371/journal.pone.0047991.
  10. Dalmeijer, G.W., van der Schouw, Y.T., Magdeleyns, E., Ahmed, N., Vermeer, C., Beulens, J.W.J. The effect of menaquinone -7 supplementation on circulating species of matrix-Gla protein. Atherosclerosis 225 (2012) 397-402.
  11. Theuwissen, E., Cranenburg, E.C.M., Knapen, M.H.J., Magdeleyns, E.J., Teunissen, K.J., Schurgers, L.J., Vermeer, C. Low dose menaquinone-7 supplementation improved extra-hepatic vitamin K2 status, but had no effect on thrombin generation in healthy subjects. Brit. J. Nutr. 108 (2012) 1652-1657.
  12. Brandenburg, V., Al-Fakhri, N., Nemeth, K., Goettsch, C., Schurgers, L.J., Vermeer, C., Hofbauer, L.C., Schoppet, M. Calcification inhibitors in vascular calciphylaxis associated with normal renal function. Thromb. Haemostas. 108 (2012) 1241-1243.

  Published patents: – Vermeer, C. Use of vitamin K for weight maintenance and weight control. Patent # WO 2012/080519, June 21, 2012.

Publication list 2011 of Associate Professor Dr. Cees Vermeer
  1. Gorgels, T.G.M.F., Waarsing, E., Herfs, M., Versteeg, D., Schoensiegel, F., Sato, T., Schlingemann, R.O., Ivandic, B., Vermeer, C., Schurgers, L.J., Bergen, A.A.B. Vitamin K supplementation increases vitamin K tissue levels but fails to counteract ectopic calcification in a mouse model for pseudoxanthoma elasticum. J. Mol. Med., epub.
  2. Schlieper, G., Westenfeld, R., Krüger, T., Cranenburg, EC.M., Magdeleyns, E.J., Brandenburg, V.M., Djuric, Z., Damjanovic, T., Ketteler, M., Vermeer, C., Dimkovic, N., Floege, J., Schurgers, L.J. Circulating nonphosphorylated carboxylated Matrix Gla Protein predicts survival in ESRD. J. Am. Soc. Nephrol., 22 (2011), 387-395.
  3. Jiang Q, Li Q, Grand-Pierre AE, Schurgers LJ, Uitto J. Administration of vitamin K does not counteract the ectopic mineralization of connective tissues in Abcc6 (-/-) mice, a model for Pseudoxanthoma elasticum. Cell Cycle 10 (2011) 701-707.
  4. Vermeer, C., Theuwissen, E. Vitamin K, Osteoporosis and Degenerative Diseases of Aging. Menopause Int. 17 (2011) 19-23.
  5. Theuwissen, E., Vermeer, C. Role of Vitamin K2 in Bone and Heart Health. In: Hot topics en vitaminas y salud.ISBN 978-84-7867-062-8. Editor: IMC, Madrid, Spain, 2011, pp 73-81.
  6. Noordzij, M., Cranenburg, E.C.M., Engelsman, L.F., Hermans, M.M., Boeschoten, E.W., Brandenburg, V.M., Bos, W.J., Kooman, J.P., Dekker, F.W., Ketteler, M., Schurgers, L.J., Krediet, R.T., Korevaar, J.C., for the NECOSAD Study Group. Progression of aortic calcification is associated with disorders of mineral metabolism and mortality in chronic dialysis patients. Nephrol. Dial. Transplant. 26 (201!) 1662-1669.
  7. Cranenburg, E.C.M., van Spaendonck-Zwarts, K.Y., Bonafe, L., Mittaz Crettol, L., Rödiger, L.A., Dikkers, F.G., van Essen, A.J., Superti-Furga, A., Alexandrakis. E., Vermeer, C., Schurgers, L.J., Laverman, G.D. Circulating Matrix Gla protein (MGP) species are refractory to vitamin K treatment in a new case of Keutel syndrome. J. Thormb. Haemostas. 9 (2011) 1225-1235.
  8. Ueland, T., Gullestad, L., Dahl, C.P., Aakhus, S., Broch, K., Vermeer, C., Aukrust, P., Schurgers, L.J. Circulating levels of non-phosphorylated uncarboxylated matrix gla protein are associated with disease severity in patients with chronic heart failure. Clin. Sci. 121 (2011) 119-127.
  9. Shea, M.K., O’Donnell, C.J., Vermeer, C., Magdeleyns, E.J.P., Crosier, M.D., Gundberg, C.M., Ordovas, J.M., Kritchevsky, S.B., Booth, S.L., Circulating uncarboxylated matrix gla protein is associated with vitamin K nutritional status, but not coronary artery calcium, in older adults. J. Nutr.141 (2011) 1529-1534.
Publication list 2006-2010 of Associate Professor Dr. Cees Vermeer
  1. Le Boulanger, G., Labrèze, C., Croué, A., Schurgers, L.J., Chassaing, N., Wittkampf, T., Rutsch, F., Martin, L. An unusual severe case of pseudoxanthoma elasticum presenting as generalized arterial calcification of infancy. Am. J. Med. Genet. 152A (2010) 118-123.
  2. Shroff, R.C., McNair, R., Skepper, J.N., Figg, N., Schurgers, L.J., Deanfield, J., Rees, L., Shananhan, C.M. Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification. J. Am. Soc. Nephrol. 21 (2010) 103-112.
  3. Ueland, T., Fougner, S.L., Godang, K., Lekva, T., Schurgers, L.J., Scholz, H., Halvorsen, B., Schreiner, T., Aukrust, P., Bollerslev, J. Associations between body composition, circulating interleukin-1 receptor antagonist, osteocalcin and insulin metabolism in active acromegaly. J Clin Endocrinol Metab. 95 (2010) 361-368.
  4. Schlieper, G., Grotemeyer, D., Aretz, A., Schurgers, L.J., Krüger, T., Rehbein, H., Weirich, T.E., Westenfeld, R., Brandenburg, V.M., Eitner, F., Mayer, J., Floege, J., Sandmann, W., Ketteler, M. Analysis of Calcifications in Patients with Coral Reef Aorta. Ann. Vasc. Surg. 24 (2010) 408-414.
  5. Schurgers, L.J., Barreto, D.V., Liaboeuf, S., Barreto, F.C., Renard, C., Magdeleyns, E.J., Vermeer, C., Choukroun, G., Massy, Z.A. The circulating inactive form of matrix Gla protein is a surrogate marker for vascular calcification in chronic kidney disease: a preliminary report. Clin. J. Am. Soc. Nephrol. 5 (2010) 568-575.
  6. Schurgers, L.J., Vermeer. C. Matrix Gla-Proteine: een vitamine K-afhankelijke remmer van vaatverkalking. Tromnibus 38 (2010) 11-16.
  7. Parker BD, Schurgers LJ, Vermeer C, Schiller NB, Whooley MA, Ix JH. The Association of Uncarboxylated Matrix Gla Protein with Mitral Annular Calcification Differs by Diabetes Status: The Heart and Soul Study. Atherosclerosis 210 (2010) 320-325.
  8. Rennenberg, R.J.M.W., de Leeuw, P.W., Kessels, A.G.H., Schurgers, L.J., Vermeer, C., van Engelshoven, J.M.A., Kemerink, G.J., Kroon, A.A. Calcium scores and matrix gla-protein levels: association with vitamin K status. Eur. J. Clin. Invest. 40 (2010) 344-349.
  9. Parker, B.D., Schurgers, L.J., Brandenburg, V.M., Christenson, R.H., Vermeer, C. Ketteler, M., Shlipak, M.G., Whooley, M.A., Ix, J.H. FGF-23, Matrix Gla Protein, Fetuin-A and Mortality in Persons with Coronary Heart Disease: The Heart and Soul Study. Ann. Int. Med. 152 (2010) 640-648.
  10. C. Vermeer. Diagnostic assay for human matrix Gla-protein and its use as a biomarker. US Patent 7,700,296 B2. Date of approval: April 20, 2010.
  11. Vanakker, O.M., Martin, L., Schurgers, L.J., Gheduzzi, D., Vermeer, C., Pasquali-Ronchetti, I., Coucke, P.J., De Paepe, A. Low serum vitamin K in PXE results in defective carboxylation of mineralization inhibitors similar to the GGCX mutations in the PXE-like syndrome. Lab. Invest. 90 (2010) 895-905.
  12. Rennenberg R.J.M.W., van Varik, B.J., Schurgers, L.J., Hamulyak, K., ten Cate, H., Leiner, T., Vermeer, C., de Leeuw, P.W., Kroon, A.A. Chronic coumarin treatment is associated with increased extra-coronary arterial calcification in humans. Blood 115 (2010) 5121-5123.
  13. Wallin, R., Schurgers, L.J., Loeser, R.F. Biosynthesis of the vitamin K-dependent matrix Gla protein (MGP) in chondrocytes: a fetuin-MGP protein complex is assembled in vesicles shed from normal but not from osteoarthitic chondrocytes. Osteoarthritis Cartilage 18 (2010) 1096-1103.
  14. Cranenburg E.C.M., Koos, R., Schurgers, L.J., Magdeleyns, E., Schoonbrood, T.H.M., Landewe, R., Brandenburg, V.M., Bekers, O., Vermeer, C. Characterization and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thromb. Haemostas. 104 (2010) 811-822.
  15. Ueland, T., Gullestad, L., Dahl, C.P., Aukrust, P., Aakhus, S., Solberg, O.G., Vermeer, C., Schurgers, L.J. Undercarboxylated matrix gla protein is associated with development of heart failure in symptomatic aortic stenosis. J. Int. Med. 268 (2010) 483-492.
  16. Cosemans, J.M.E.M., Munnix, I.C.A., Schurgers, L.J., Schols, S.E.M., Angelillo-Scherrer, A., Hoylaerts, M., Carmeliet, P., Heemskerk, J.W.M. Roles of human and mouse Gas6 and Gas6 receptors in the formation and stabilization of thrombi. J. Thromb. Haemostas 8 (2010) 1797-1808.
  17. Rennenberg, R.J., Schurgers, L.J., Kroon, A.A., Stehouwer, C.D. Arterial calcifications. J. Cell Mol. Med. 14 (2010) 2203-2210.
  18. van Hasselt, P.M., de Vries, W., de Vries, E., Kok, K., Cranenburg, E.C.M., de Koning, T.J., Schurgers, L.J., Verkade, H.J., Houwen, R.H.J. Hydrolysed formula is a risk factor for vitamin K deficiency in infants with unrecognised cholestasis. J. Pediatr. Gastroenterol. Nutr. 51 (2010) 773-776.
  19. Hristova, M., van Beek, C., Schurgers, L.J., Lanske, B., Danziger, J. Rapidly progressive severe vascular calcification sparing the kidney allograft following warfarin initiation. Am. J. Kidney Dis. 56 (2010), 1158-1162.
  20. Cranenburg, E.C.M., Brandenburg, V.M., Westenfeld, R., Krueger, T., Stenger, M., Vermeer, C., Schurgers, L.J., Ketteler, M. Matrix-Gla Protein (MGP) is associated with the amount of coronary artery calcification in HD patients as assessed by MSCT Agatston score. Thromb. Haemostas. 101 (2009) 359-366.
  21. Li, Q., Schurgers, L.J., Smithm A.C., Tsokos, M., Uitto, J., Cowen, E.W. Co-existent Pseudoxanthoma Elasticum and vitamin K-dependent coagulation factor deficiency. Compound heterozygosity for mutations in the GGCX gene. Am. J. Pathol. 174 (2009) 534-540.
  22. Li, Q., Grange, D.K., Armstrong, N.L., Whelan, A.J., Hurley, M.Y., Rishavy, M., Hallgren, K., Berkner, K.L., Schurgers, L.J., Jiang, Q., Uitto, J. Mutations in the GGCX and ABCC6 Genes in a Family with Pseudoxanthoma Elasticum-like Phenotypes. J. Invest. Dermatol. 129 (2009) 553-563.
  23. Koos, R.,Kühl, H.P., Brandenburg, V., Mahnken, A.H., Stanzel, S., Flöge, J., Kelm, M., Vermeer, C., Schurgers, L.J. Relation of circulating matrix-gla-protein and anticoagulation status in patients with aortic valve calcification. Thromb. Haemostas. 101 (2009) 706-713.
  24. Krueger, T., Westenfeld, R., Schurgers, L., Brandenburg, V. Coagulation meets calcification: the vitamin K system. Int. J. Artif. Organs 32 (2009) 67-74.
  25. Schlieper, G., Brandenburg, V., Djuric, Z., Damjanovic, T., Markovic, N., Schurgers, L.J., Krüger, T., Westenfeld, R., Ackermann, D., Haselhuhn, A., Dimkovic, S., Ketteler, M., Floege, J., Dimkovic, N. Risk factors for cardiovascular calcifications in non-diabetic caucasian haemodialysis patients. Kidney Blood Press. Res. 32 (2009) 161-168.
  26. Rennenberg, R.J., Kessels, A.G., Schurgers, L.J., van Engelshoven, J.M., de Leeuw, P.W., Kroon, A.A. Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis. Vasc. Health Risk Manag. 5 (2009) 185-197.
  27. Westenfeld, R., Schäfer, C., Krüger, T., Haarmann, C., Schurgers, L.J., Reutelingsperger, C., Ivanovski, O., Druecke, T., Massy, Z.A., Ketteler, M., Floege, J., Jahnen-Dechent, W. Fetuin-A protects against atherosclerotic calcifications in mice with renal failure. J. Am. Soc. Nephrol. 20 (2009) 1264-1274.
  28. Krueger, T., Westenfeld, R., Ketteler, M., Schurgers, L.J., Floege, J. Vitamin K deficiency in CKD patients: a modifiable risk factor for vascular calcification? Kidney Int. 76 (2009) 18-22.
  29. Parker, B.D., Ix, J.H., Cranenburg, E.C.M., Vermeer, C., Whooley, M.A., Schurgers, L.J. Association of kidney function and uncarboxylated Matrix Gla Protein: data from the Heart and Soul Study. Nephrol. Dial. Transplant. 24 (2009) 2095-2101.
  30. Mertsch, S., Schurgers, L.J., Weber, K., Paulus, W., Senner, V. Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastoma. BMC Cancer 9 (2009) 302.
  31. Van Summeren, M.H.J., Braam, L.A.J.L.M., Lilien, M.R., Schurgers, L.J., Kuis, W., Vermeer, C. The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children Brit. J. Nutr. 102 (2009) 1171-1178.
  32. Le Boulanger, G., Labrèze, C., Croué, A., Schurgers, L.J., Chassaing, N., Wittkampf, T., Rutsch, F., Martin, L. An unusual severe case of pseudoxanthoma elasticum presenting as generalized arterial calcification of infancy. Am. J.Med. Genet. 152A (2010) 118-123.
  33. Card, D., Shearer, M.J., Schurgers, L.J., Harrington, D.J. The external quality assurance of phylloquinone (vitamin K1) analysis in human serum. Biomed. Chromatogr. 23 (2009) 1276-1282.
  34. Schurgers, L.J., Vermeer C. Vitamine K: meer dan alleen een cofactor voor stolling. Tromnibus 37 (2009) 49-54. Patent: Vermeer, C. Anti-thrombotic effects of vitamin K. International filing date: 17.09.2009.
  35. Van Summeren, M.J.H., Spliet, W.G.M., van Royen-Kerkhof, A., Vermeer, C., Lilien, M., Kuis, W., Schurgers, L.J. Calcinosis in juvenile dermatomyositis: a possible role for the vitamin K-dependent protein MGP. Rheumatol. 47 (2008) 267-271.
  36. Golledge, J., Jayalath, R., Oliver, L., Parr, A., Schurgers, L., Clancy, P. Relationship between CT anthropometric measurements, adipokines and abnormal aortic calcification. Atherosclerosis 197 (2008) 428-432.
  37. Cranenburg, E.C.M., Vermeer, C., Koos, R., Boumans, M.-L., Kwaijtaal, M., Ketteler, M., Brandenburg, V., Schurgers, L.J. The circulating inactive form of Matrix Gla Protein (ucMGP) as a biomarker for cardiovascular disease. J. Vasc. Res. 45 (2008) 427-436.
  38. Van Summeren, M.J.H., Vermeer, C., Engelbert, R.H.H., Schurgers, L.J., Takken, T., Fischer, K., Kuis, W. Extremes in vitamin K status of bone are related to bone ultrasound properties in children with juvenile idiopathic arthritis. Clin. Exptl. Rheumatol. 26 (2008) 484-491.
  39. Van Summeren, M.H.J., Hameleers, J., Schurgers, L.J., Hoeks, A.P.G., Uiterwaal, C.S.P.M., Krüger, T., Vermeer, C., Kuis, W., Lilien, M.R. Circulating levels of calcification inhibitors and vascular properties in children after renal transplantation. Pediatr. Nephrol. 23 (2008) 985-993.
  40. Wallin, R., Schurgers, L.J., Wajih, N. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. Thromb. Res. 122 (2008) 411-417.
  41. Van Summeren, M.J.H., van Coeverden, S.C.C.M., Schurgers, L.J., Braam, L.A.J.L.M., Noirt, F., Uiterwaal, C., Kuis, W., Vermeer, C. Vitamin K status is associated with childhood bone mineral content. Brit. J. Nutr 100 (2008) 852-858.
  42. Shroff, R.C., Shah, V., Hiorns, M.P., Schoppet, M., Hofbauer, L.C., Hawa, G., Schurgers, L.J., Singhal, A., Merryweather, I., Brogan, P., Shanahan, C., Deanfield, J., Rees, L. The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not Matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis. Nephrol. Dial. Transplant. 23 (2008) 3262-3271.
  43. Schurgers, L.J., Cranenburg, E., Vermeer, C. Matrix Gla-protein: the calcification inhibitor in need of vitamin K. Thromb. Haemostas. 100 (2008) 593-603.
  44. Vermeer, C. Vitamin K, Matrix Gla-protein and vascular calcification: treatment options of vascular complications in renal disease. Wiener Medizinische Wochenschrift Skriptum 5/11 (2008) 12-13.
  45. Shroff, R.C., McNair, R., Figg, N., Skepper, J.N., Schurgers, L.J., Gupta, A., Hiorns, M., Donald, A.E., Deanfield, J., Rees, L., Shanahan, C.M. Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation. 118 (2008) 1748-1757.
  46. Vanschoonbeek, K., Wouters, K., van der Meijden, P.E.J., van Gorp, P.J., Feijge, M.A.H., Herfs, M., Schurgers, L.J., Hofker,M.H., de Maat, M.P.M., Heemskerk, J.W.M. Anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in APOE2 knock-in mice. Arterioscler. Thromb. Vasc. Biol. 28 (2008) 2023-2029.
  47. Rennenberg, R.J.M.W., Schurgers, L.J., Vermeer, C., Houben, A.J.H.M., de Leeuw, P.W., Kroon, A.A. Renal handling of matrix gla-protein in humans with moderate to severe hypertension. Hypertension Research 31 (2008) 1745-1751.
  48. Schlieper, G., Krüger, T., Djuric, Z., Damjanovic, T., Markovic, N., Schurgers, L.J., Brandenburg, V., Westenfeld, R., Dimkovic, S., Ketteler, M., Grootendorst, D.C., Dekker, F., Floege, J., Dimkovic, N. Vascular access calcification predicts mortality in hemodialysis patients. Kidney International 74 (2008) 1582-1587.
  49. Bügel, S., Sorensen, A.D., Hels, O., Vermeer, C., Jakobsen, J., Flynn, A., Molgaard, C., Cashman, K. Effect of vitamin K on bone markers in postmenopausal women. EurNutr. 97 (2007) 373-380.
  50. Van Summeren, C.M.J.H., Braam, L., Noirt, F., Kuis, W., Vermeer, C. Pronounced elevation of undercarboxylated osteocalcin in healthy children. Ped. Res. 61 (2007) 366-370.
  51. Schurgers, L.J., Spronk, H.M.H., Soute, B.A.M., Schiffers, P.M., DeMey, J.G.R., Vermeer, C. Regression of arterial medial calcification after high intake of vitamin K. Blood 18 (2007) 2823-2831.
  52. Knapen, M.H.J., Schurgers, L.J., Vermeer, C. Vitamin K2 supplementation improves bone geometry and bone strength indices in postmenopausal women. Osteoporosis International 18 (2007) 963-972.
  53. Schurgers, L.J., Teunissen, K.J.F., Hamulyák, K., Knapen, M.H.J., Vik, H., Vermeer, C. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood 109 (2007) 3279-3283.
  54. Stafford, D.W., Roberts, H., Vermeer, C. Vitamin K supplementation during oral anticoagulation: cautions. Blood 109 (2007) 3607-3608.
  55. Schurgers, L.J., Knapen, M.H.J., Vermeer, C. Vitamin K2 improves bone strength in postmenopausal women. Elsevier International Congress Series 1297 (2007) 179-187.
  56. Cranenburg, E.C.M., Schurgers, L.J., Vermeer, C. Vitamin K, the coagulation vitamin that became omnipotent. Thromb. Haemostas. 98 (2007) 120-125.
  57. Cario-Toumaniantz, C., Boularan, C., Schurgers, L.J., Heymann, M.F., Le Cunff, M., Léger, J., Loirand, G., Pacaud, P. Identification of differentially expressed genes in human varicose veins: involvement of Matrix Gla-Protein in extracellular matrix. J Vasc. Res. 44 (2007) 444-459.
  58. Göritz, C., Thiebaut, R., Tessier, L.-H., Nieweg, K., Moehle, C., Buard, I., Dupont, J.-L., Schurgers, L.J., Schmitz, G., Pfrieger, F.W. Glia-induced neuronal differentiation by transcriptional regulation. Glia 55 (2007) 1108-1122.
  59. Hermans, M.M.H., Vermeer, C., Kooman, J.P., Brandenburg, V., Ketteler, M, Gladziwa, U., RensmaP.L., Leunissen, K.M.L., Schurgers, L.J., Undercarboxylated matrix-Gla protein levels are decreased in dialysis patients and related to parameters of calcium-phosphate metabolism and aortic augmentation index. Blood Purification 25 (2007) 395-401.
  60. Gheduzzi, D., Boraldi, F., Giulia, A., DeVincenzi Chiara, P., Schurgers, L.J., Vermeer, C., Quaglino, D., Pasquali Ronchetti, I. Matrix Gla Protein (MGP) in Pseudoxanthoma Elasticum (PXE) and in genetic disorders with PXE-like clinical manifestations. Lab Invest. 87 (2007) 998-1008.
  61. Vermeer, C. Diagnostic assay for human Matrix Gla-Protein and its use as a biomarker. EU Patent Nr. 1190259. Eur. Patent Bull. 46 (2007) 14 november
  62. Li, Q., Jiang, Q., Schurgers, L.J., Uitto, J. Pseudoxanthoma elasticum: reduced gammaglutamyl carboxylation of matrix gla protein in a mouse model (Abvv6-/-). Biochem. Biophys. Res. Commun. 364 (2007) 208-213.
  63. Schurgers, L.J., Spronk, H.M.H., Soute, B.A.M., Vermeer, C., Weissberg, P.L., Shanahan, C.M., Proudfoot, D. Posttranslational modifications regulate matrix Gla protein (MGP) function: importance for inhibition of vascular smooth muscle cell calcification. J. Thromb. Haemostas. 5 (2007) 2503-2511.
  64. Vermeer, C., Schurgers, L.J. Importance of vitamin K for bone health. In: Bone health and vascular health in chronic inflammation. Ed.: Capraru, C. ISBN 978-973-35-2317-8 (2007) pp 10-14.
  65. Vermeer, C., Schurgers, L.J. Importance of vitamin K for vascular health. In: Bone health and vascular health in chronic inflammation. Ed.: Capraru, C. ISBN 978-973-35-2317-8 (2007) pp 59-63.
  66. Van Langendonckt A, Punyadeera C, Kamps R, Dunselman G, Schurgers LJ, Squifflet J, Donnez J, Groothuis P. Identification of novel antigens in blood vessels in rectovaginal endometriosis. Mol. Hum. Reprod. 13 (2007) 875-886.
  67. Janzen, J., Schurgers, L.J., Vermeer, C., Joris, F., Musy, J.-.P, Schmidli, J. Mediakalzifikationen in einem Aneurysma des Arcus aortae. Perfusion 19 (2006) 237-241.
  68. Panis, B., Vermeer, C., van Kroonenberg, M.J., Nieman, F.H., Menheere, P.P., Spaapen, L.J., Rubio-Gozalbo, M.E. Effect of calcium, vitamins K(1) and D(3) on bone in galactosemia. Bone 39 (2006) 1123-1129.
  69. Willems, H.P., den Heijer, M., Gerrits, W.B., Schurgers, L.J., Havekes, M., Blom H.J., Bos, G.M. Oral anticoagulant treatment with coumarin derivatives does not influence plasma homocysteine concentration. Eur. J. Intern. Med. 17 (2006) 120-124.
  70. Johnson, J.S., Soute, B.A.M., Olver, C.S., Baker, D.C. Defective gamma-glutamyl carboxylase activity and bleeding in Rambouillet sheep. Vet. Pathol. 43 (2006) 726-732.
  71. Thijssen, H.H.W., Vervoort, L.M.T., Schurgers, L.J., Shearer, M.J. Menadione is a metabolite of K-vitamins; an explanation of the route of conversion of phylloquinone into menaquinone-4. Brit. J. Nutr. 95 (2006) 260-266.  
Publication list 2000-2005 of Associate Professor Dr. Cees Vermeer
  1. Ayşe Y. Demir, Patrick G. Groothuis, Gerard A. J. Dunselman, Leon J. Schurgers, Johannes L. H. Evers, Anton F. P. M. de Goeij. Molecular characterization of soluble factors from human menstrual effluent that induce epithelial to mesenchymal transitions in mesothelial cells. Cell Tissue Res. 2005 Aug 5;:1-13 (ipf 2.67)
  2. Schurgers, L.J., Teunissen, K.J.F., Knapen, M.H.J., Kwaijtaal, M., van Diest, R., Appels, A., Reutelingsperger, C.P., Cleutjens, J.P.M., Vermeer, C. (2005). Novel conformation-specific antibodies against matrix Gla-protein: undercarboxylated matrix Gla protein as marker for vascular calcification. Arterioscler. Thromb. Vasc. Biol. 25, 1629-1633.
  3. Vermeer, C., Schurgers, L.J. (2005). Direct testing for deficiencies. Ingredients, Health & Nutrition 8, 10-12.
  4. Schurgers, L.J., Teunissen, K., Knapen, M.H.J., Geusens, P., van der Heijde, D., Kwaijtaal, M., van Diest, R., Ketteler, M., Vermeer, C. (2005). Characteristics and performance of an immunosorbent assay for human matrix Gla-protein (MGP). Clin. Chim. Acta 351, 131-138.
  5. Smith, C.I., Craig, O.E., Prigodich, R.V., Nielsen-Marsh, C.M., Jans, M.M.E., Vermeer, C., Collins, M.J. Diagenesis and survival of osteocalcin in archaeological bone. J. Arch. Sci. 32 (2005) 105-113.
  6. Kobayashi, N., Kitazawa, R., Maeda, S., Schurgers, L.J., Kitazawa, S. (2004). T-138C polymorphism of matrix Gla protein promotor alters its expression but is not directly associated with atherosclerotic vascular calcification. Kobe J. Med. Sci. 50, 1-13.
  7. Vermeer, C., Hamulyák, K. (2004). Vitamin K: lessons from the past. J. Thromb. Haemostas. 2, 2115-2117
  8. Reynolds, J.L., Joannides, A.J., Skepper, J.N., McNair, R., Schurgers, L.J., Proudfoot, D., Weissberg, P.L., Shanahan, C.M. (2004). Vesicle-mediated calcification of human smooth muscle cells in response to changes in extracellular mineral. A mechanism for accelerated vascular calcification in end-stage renal disease. J. Am. Soc. Nephrol. 15, 2857-2867.
  9. Geleijnse, J.M., Vermeer, C., Grobbee, D.E., Pols, H.A.P., Schurgers, L.J., Knapen, M.H.J., van der Meer, I.M., Hofman, A., Witteman, J.C.M. (2004). Dietary intake of vitamin K-2 reduces the risk of cardiac events and aortic atherosclerosis: The Rotterdam Study. J. Nutr. 134, 3100-3105.
  10. Ryan, B.M., Russel, M.G.V.M., Schurgers, L.J., Wichers, M., Sijbrandij, J., Stockbrugger, R.W., Schoon, E. (2004). Effect of antitumour necrosis factor-alpha therapy on bone turnover in patients with Crohn’s disease: a prospective study. Alimentary Pharmacology and Therapeutics 20, 851-857.
  11. Thijssen H.H.W., Soute, B.A.M., Vervoort, L.M.T., Claessens, J.G. (2004). Paracetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycle. Thromb. Haemstas. 92, 797-802. Vermeer, C., Braam, L.A.J.L.M. (2004). Increased vitamin K intake may decrease bone loss. Osteoporosis Review 12, 11-14.
  12. Schurgers, L.J., Aebert, H., Vermeer, C., Bültmann, B., Janzen, J. (2004). Oral anticoagulant treatment: friend or foe in cardiovascular disease? Blood 104, 3231-3232.
  13. Schurgers, L.J., Shearer, M.J., Hamulyák, K., Stöcklin, E., Vermeer, C. (2004). Effect of vitamin K on the stability of oral anticoagulant treatment: dose response relationship in healthy subjects. Blood 104, 2682-2689.
  14. Panis, B., Forget, P.Ph., van Kroonenburgh, M.J.P.G., Vermeer, C., Menheere, P.P., Nieman, F.H., Rubio-Gozalbo, M.E. (2004). Bone metabolism in Galactosemia. Bone 35, 982-987.
  15. Thijssen H.H.W, Soute, B.A.M, Vervoort, L.M.T., Claessens, J.G. (2004). Paracetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycle. Thromb. Haemstas. 92, 797-802.
  16. Braam, L., McKeown, N., Jacques, P., Lichtenstein, A., Vermeer, C., Wilson, P., Booth, S. (2004). Dietary phylloquinone intake as a potential marker for heart-healthy dietary pattern in the Framingham Offspring cohort. J. Am. Dietet. Nutr. 104, 1410-1414.
  17. Vermeer, C., Shearer, M.J., Zittermann, A., Bolton-Smith, C., Szulc, P., Hodges, P., Walter, P., Rambeck, W., Stöcklin, E., Weber, P. (2004). Beyond deficiency: potential benefits of increased intakes of vitamin K for bone and vascular health. Eur. J. Nutr. 43, 1-11.
  18. Soute B.A.M., Jin, D.Y., Spronk, H.M.H., Mutucumarana, V., Lin, P.J., Hackeng, T.M., Stafford, D.W., Vermeer, C. (2004). Characteristics of recombinant W501S mutated human γ-glutamyl carboxyase. J. Thromb. Haemostas. 2, 597-604.Jono, S., Ikari, Y., Vermeer, C., Dissel, P., Hasegawa, K., Shioi, A., Taniwaki, H., Kizu, A., Nishizawa, Y. Saito, S. (2004). Matrix Gla-protein is associated with coronary artery calcification as assessed by electron-beam computed tomography. Thromb. Haemostas. 91, 790-794.Vermeer, C. (2004). Vitamin K and cardiovascular health – what is the optimum? Brit. J. Cardiol. 11, S4-S5. Braam, L.A.J.L.M., Hoeks, A.P.G., Brouns, F., Hamulyák, K., Gerichhausen, M.J.W., Vermeer, C. (2004). Beneficial effects of vitamin K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study. Thromb. Haemostas. 91, 373-380.Vermeer, C., Braam, L., Knapen,. M., Schurgers, L. (2003). Vitamin K supplementation: a simple way to improve bone and vascular health. Agrofood Industry Hi-Tech 14, 17-20.Vermeer, C., Schurgers, L.J., Braam, L.A.J.L.M. (2003). Potential applications of vitamin K-containing products. Nutracos 5, 13-16.van Hoorn, J.H.L., Hendriks, J.J.E., Vermeer, C., Forget, P.Ph. (2003). Vitamin K supplementation in cystic fibrosis. Arch. Dis. Child. 88, 974-975.Braam, L.A.J.L.M., Knapen, M.H.J., Geusens, P., Brouns, F., Vermeer, C. (2003). Factors affecting bone loss in female endurance athletes: a two-year follow -up study. Am. J. Sports Med. 31, 889-895.Spronk, H.M.H., Soute, B.A.M., Schurgers, L.J., De Mey, J.G.R., Vermeer, C. (2003). Tissue-specific utilisation of menaquinone-4 results in prevention of arterial calcification in warfarin-treated rats, J. Vasc. Res. 40, 531-537.Mosler, K., von Kries, R., Vermeer, C., Saupe, J., Schmitz, T., Schuster, A. (2003). Assessment of vitamin K deficiency in CF – how much sophistication is useful? J. Cyst. Fibros. 2, 91-96.Vermeer, C. (2003). Vitamin K and bone health. Curr. Topics in Nutraceut. Res. 1, 73-84.Ketteler, M., Wanner, C., Metzger, T., Bongartz, P., Westenfeld, R., Gladziwa, U., Schurgers, L.J., Vermeer, C., Jahnen-Dechent, W. Floege, J. (2003). Deficiencies of calcium-regulatory proteins in dialysis patients: a novel concept of cardiovascular calcification in uremia. Kidney Int. Suppl. 84, 84-87.Braam, L.A.J.L.M., Knapen, M.H.J., Geusens, P., Brouns, F., Hamulyák, K., Gerichhausen, M.J.W., Vermeer, C. (2003). Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age. Calcif. Tissue Int. 73, 21-26. Vermeer, C., Braam, L., Schurgers, L. (2002). Vitamin K-enrichment: a new challenge for functional foods that target cardiovascular and bone health. IHN Magazine 5, 12-16. Graff, I.E., Waagbø, R., Fivelstad, S., Vermeer, C., Lie, Ø, Lundebye, A.K. (2002). A multivariate study on the effects of vitamin K, vitamin D3, calcium, and water carbon dioxide on growth, bone minerals, vitamin status and health performance in smolting Atlantic salmon Salmo salar L. J. Fish Dis. 25, 599-614. Vermeer, C., L. Braam, L. Schurgers, F. Brouns. (2002). Increased vitamin K intake by functional foods or food supplements: a new lead to improve cardiovascular and bone health. Agrofood Industry Hi-Tech 13, 11-15. Ketteler, M., Vermeer, C., Wanner, C., Westenfeld, R., Jahnen-Dechent, W., Floege, J. (2002). Novel insights into uremic calcification: role of Matrix Gla-Protein and α2-Hermans-Schmid Glycoprotein / fetuin. Blood Purif. 20, 473-476. Rubio-Gozalbo, M.E., Hamming, S., van Kroonenburgh, M.J.P.G., Bakker, J.A., Vermeer, C., Forget, P.Ph. (2002). Decreased bone mineral density in patients with classic galactosemia. Arch. Dis. Childh. 87, 57-60. Schurgers, L.J., Shearer, M.J., Soute, B.A.M., Elmadfa, I., Harvey, J., Wagner, K.-H., Tomasch, R., Vermeer, C. (2002). Novel effects of diets enriched with corn oil or with an olive/sunflowerseed oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men. J. Lipid Res. 43, 878-884. Houben, R.J.T.J., Rijkers, D.T.S., Stanley, T.B., Acher, F., Azerad, R., Käkönen, S.-M., Vermeer, C., Soute, B.A.M. (2002). Characteristics and composition of the vitamin K-dependent γ-glutamyl carboxylase binding domain on osteocalcin. Biochem. J. 364, 323-328. Schurgers, L.J., Vermeer, C. (2002). Differential lipoprotein transport pathways of K-vitamins in healthy subjects. Biochim. Biophys. Acta 1570, 27-32. Penning-van Beest, F.J.A., Geleinse, J.M., van Meegen, E., Vermeer, C., Rosendaal, F.R., Stricker, B.H.Ch. (2002). Lifestyle and diet as risk factors related to overanticoagulation. J. Clin. Epidemiol. 55, 411-417. Celie, P.H.N., van Stempvoort, G., Fribourg, C., Schurgers, L.J., Lenting, P.J., Mertens, K. (2002). The connecting segment between both epidermal growth factor-like domains in blood coagulation factor IX contributes to stimulation by factor VIIIa and its isolated A2 domain. J. Biol. Chem. 277, 20214-20220. Thijssen, H.H.W., Drittij, M.J., Vermeer, C., Schoffelen, E. (2002). Menaquinone-4 in breast milk is derived from dietary phylloquinone. Brit. J. Nutr. 87, 219-226. Dhore, C.R., Cleutjens, J.P.M., Lutgens, E., Cleutjens, K.B.J.M., Geussens, P., Kitslaar, P.J.E.H.M., Tordoir, J.H.M., Spronk, H.M.H., Vermeer, C., Daemen, M.J.A.P. (2001). Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscl. Thromb. Vasc. Biol., 21, 1998-2003. Spronk, H.M.H., Soute, B.A.M., Schurgers, L.J., Cleutjens, J.P.M., Thijssen, H.H.W., De Mey, J.G.R., Vermeer, C. (2001). Matrix Gla protein accumulates between tissue and calcium deposits in the arterial vessel wall, Biochem. Biophys. Res. Commun. 289, 485-490. Mousallem, M., Spronk, H.M.H., Sacy, R., Hakime, N., Soute, B.A.M. (2001) Congenital Combined Deficiencies Of All Vitamin K- Dependent Coagulation Factors. Thromb. Haemostas. 86, 1334-1336. Schurgers, L.J., Dissel, P.E.P., Spronk, H.M.H., Soute, B.A.M., Dhore, C.R., Cleutjens, J.P.M., Vermeer, C. (2001). Role of vitamin K and vitamin K-dependent proteins in vascular calcification. Z. Kardiol. 90:Suppl. 3, III/57-III63. Nieuwenhuys, C.M., Feijge, M.A., Vermeer, C., Hennissen, A.H., Beguin, S., Heemskerk, J.W. (2001) Vitamin K-dependent and vitamin K-independent hypocoagulant effects of dietary fish oil in rats. Thromb. Res. 104, 137-147. Vermeer, C., Braam, L. (2001) Role of K vitamins in the regulation of tissue calcification. J. Bone. Miner. Metab. 19, 201-206 Schurgers, L.J., Vermeer, C. (2001) Corn oil-induced decrease in arterial thrombosis tendency may be related to altered plasma vitamin K transport. J. Lipid. Res. 42, 1120-1124. Farzaneh-Far, A., Davies, J.D., Braam, L.A., Spronk, H.M., Proudfoot, D., Chan, S.W., O’Shaughnessy, K.M., Weissberg, P.L., Vermeer, C., Shanahan, C.M. (2001) A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels.J. Biol. Chem. 276, 32466-32473. Schoon, E.J., Geerling, B.G., Van Dooren, I.M., Schurgers, L.J., Vermeer, C., Brummer, R.J., Stockbrugger, R.W. (2001). Abnormal bone turnover in long-standing Crohn’s disease in remission. Aliment. Pharmacol. Ther. 15, 783-792. Hackeng, T.M., Rosing, J., Spronk, H.M.H., Vermeer, C. (2001)Total chemical synthesis of human matrix Gla protein. Proteine Science 10, 864-870. Schoon E.J., Muller M.C., Vermeer C., Schurgers L.J., Brummer R.J., Stockbrugger R.W. (2001) Low serum and bone vitamin K status in patients with longstanding Crohn’s disease: another pathogenetic factor of osteoporosis in Crohn’s disease? Gut 48, 473-477. Vermeer C., Thijssen H.H., Hamulyak K. (2001) Vitamin K and tissue mineralization. Bibl Nutr Dieta 55, 159-170. Oldenburg J., von Brederlow B., Fregin A., Rost S., Wolz W., Eberl W., Eber S., Lenz E., Schwaab R., Brackmann H.H., Effenberger W., Harbrecht U., Schurgers L.J., Vermeer C., Muller C.R. (2000) Congenital deficiency of vitamin K dependent coagulation factors in two families presents as a genetic defect of the vitamin K-epoxide-reductase-complex. Thromb Haemost 84, 937-941. Spronk H.M.H, Farah R.A., Buchanan G.R., Vermeer C., Soute B.A.M. (2000) Novel mutation in the gamma-glutamyl carboxylase gene resulting in congenital combined deficiency of all vitamin K-dependent blood coagulation factors. Blood 96, 3650-3652 Gijsbers B.L., Vermeer C. (2000) Carrier-linked peptides as a reference compound in enzyme-linked immunosorbent assays. Anal Biochem 284, 430-432. Braam L.A., Dissel P., Gijsbers B.L., Spronk H.M.H., Hamulyak K., Soute B.A.M., Debie W.,Vermeer C. (2000) Assay for Human Matrix Gla Protein in Serum : Potential Applications in the Cardiovascular Field. Arterioscler Thromb Vasc Biol. 20, 1257-12611. Craciun A.M., Vermeer C., Eisenwiener H.G., Drees N., Knapen M.H. (2000) Evaluation of a bead-based enzyme immunoassay for the rapid detection of osteocalcin in human serum. Clin Chem. 46, 252-257. Koivu-Tikkanen T.J., Schurgers L.J., Thijssen H.H., Vermeer C. Intestinal, hepatic, and circulating vitamin K levels at low and high intakes of vitamin K in rats. Br J Nutr. 83, 185-190. Vermeer C., Schurgers L.J. (2000) A comprehensive review of vitamin K and vitamin K antagonists. Hematol Oncol Clin North Am. 14, 339-353
Publication list 1990-1999 of Associate Professor Dr. Cees Vermeer
  1. Houben, R. J. T. J., Jin, D., Stafford, D. W., Proost, P., Ebberink, R. H. M., Vermeer, C., Soute, B.A.M. (1999) Osteocalcin binds tightly to the g-glutamylcarboxylase at a site distinct from that of the other known vitamin K-dependent proteins. Biochem. J. 341, 265-269Schürgers, L.J., Geleijnse, J.M., Grobbee, D.E., Pols, H. A. P., Hofman, A., Witeman, J.C.M., Vermeer, C. (1999) Nutritional intake of vitamins K1 (phylloquinone) and K2 (menaquinone) in The Netherlands. Journal of Nutritional & Environmental Medicine 9, 115-122.Craciun, A. M., Wolf, J., Knapen, M. H., Brouns, F., and Vermeer, C. (1998). Improved bone metabolism in female elite athletes after vitamin K supplementation. Int J Sports Med 19, 479-84. Craciun, A. M., Groenen-van Dooren, M. M., Thijssen, H. H., and Vermeer, C. (1998). Induction of prothrombin synthesis by K-vitamins compared in vitamin K- deficient and in brodifacoum-treated rats. Biochim Biophys Acta 1380, 75-81.Knapen, M. H., Nieuwenhuijzen Kruseman, A. C., Wouters, R. S., and Vermeer, C. (1998). Correlation of serum osteocalcin fractions with bone mineral density in women during the first 10 years after menopause. Calcif Tissue Int 63, 375-9.Ronden, J. E., Drittij-Reijnders, M. J., Vermeer, C., and Thijssen, H. H. (1998). Intestinal flora is not an intermediate in the phylloquinone- menaquinone-4 conversion in the rat. Biochim Biophys Acta 1379, 69-75. Ronden, J. E., Thijssen, H. H., and Vermeer, C. (1998). Tissue distribution of K-vitamers under different nutritional regimens in the rat. Biochim Biophys Acta 1379, 16-22. Vermeer, C., Knapen, M. H., and Schurgers, L. J. (1998). Vitamin K and metabolic bone disease. J Clin Pathol 51, 424-6.Craciun, A. M., Groenen-van Dooren, M. M., and Vermeer, C. (1997). Nutritional vitamin K-intake and urinary gamma-carboxyglutamate excretion in the rat. Biochim Biophys Acta 1334, 44-50.Houben, R., Soute, B. A., Knapen, M. H., and Vermeer, C. (1997). Strategies for developing human osteocalcin standards: a critical evaluation. Scand J Clin Lab Invest Suppl 227, 100-4.Houben, R. J., Soute, B. A., and Vermeer, C. (1997). Assay of vitamin K-dependent carboxylase activity in hepatic and extrahepatic tissues. Methods Enzymol 282, 358-68.Ronden, J. E., Groenen-van Dooren, M. M., Hornstra, G., and Vermeer, C. (1997). Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. Atherosclerosis 132, 61-7.Gijsbers, B. L., Jie, K. S., and Vermeer, C. (1996). Effect of food composition on vitamin K absorption in human volunteers. Br J Nutr 76, 223-9.Jie, K. G., Bots, M. L., Vermeer, C., Witteman, J. C., and Grobbee, D. E. (1996). Vitamin K status and bone mass in women with and without aortic atherosclerosis: a population-based study. Calcif Tissue Int 59, 352-6. Knapen, M. H., Eisenwiener, H. G., and Vermeer, C. (1996). Osteocalcin detection in aging serum and whole blood: stability of different osteocalcin fractions. Clin Chim Acta 256, 151-64.Ronden, J. E., Soute, B. A., Thijssen, H. H., Saupe, J., and Vermeer, C. (1996). Natural prenylquinones inhibit the enzymes of the vitamin K cycle in vitro. Biochim Biophys Acta 1298, 87-94. Vermeer, C., Gijsbers, B. L., Craciun, A. M., Groenen-van Dooren, M. M., and Knapen, M. H. (1996). Effects of vitamin K on bone mass and bone metabolism. J Nutr 126, 1187S-91S. Groenen-van Dooren, M. M., Ronden, J. E., Soute, B. A., and Vermeer, C. (1995). Bioavailability of phylloquinone and menaquinones after oral and colorectal administration in vitamin K-deficient rats. Biochem Pharmacol 50, 797-801. Jie, K. S., Bots, M. L., Vermeer, C., Witteman, J. C., and Grobbee, D. E. (1995). Vitamin K intake and osteocalcin levels in women with and without aortic atherosclerosis: a population-based study. Atherosclerosis 116, 117-23. Jie, K. S., Gijsbers, B. L., and Vermeer, C. (1995). A specific colorimetric staining method for gamma-carboxyglutamic acid- containing proteins in polyacrylamide gels. Anal Biochem 224, 163-5. Jie, K. S., Knapen, M. H., Hellemons, B. S., Hamulyak, K., and Vermeer, C. (1995). [Vitamin K: current viewpoints in connection with bone metabolism]. Ned Tijdschr Geneeskd 139, 875-80. Vermeer, C., Jie, K. S., and Knapen, M. H. (1995). Role of vitamin K in bone metabolism. Annu Rev Nutr 15, 1-22. Buitenhuis, H. C., Soute, B. A., and Vermeer, C. (1990). Comparison of the vitamins K1, K2 and K3 as cofactors for the hepatic vitamin K-dependent carboxylase. Biochim Biophys Acta 1034, 170-5. Saupe, J., Ronden, J. E., Soute, B. A., and Vermeer, C. (1994). Vitamin K-antagonistic effect of plastoquinone and ubiquinone derivatives in vitro. FEBS Lett 338, 143-6. Groenen-van Dooren, M. M., Soute, B. A., Jie, K. S., Thijssen, H. H., and Vermeer, C. (1993). The relative effects of phylloquinone and menaquinone-4 on the blood coagulation factor synthesis in vitamin K-deficient rats. Biochem Pharmacol 46, 433-7. Jie, K. S., Gijsbers, B. L., Knapen, M. H., Hamulyak, K., Frank, H. L., and Vermeer, C. (1993). Effects of vitamin K and oral anticoagulants on urinary calcium excretion. Br J Haematol 83, 100-4. Knapen, M. H., Jie, K. S., Hamulyak, K., and Vermeer, C. (1993). Vitamin K-induced changes in markers for osteoblast activity and urinary calcium loss. Calcif Tissue Int 53, 81-5. Morris, D. P., Soute, B. A., Vermeer, C., and Stafford, D. W. (1993). Characterization of the purified vitamin K-dependent gamma-glutamyl carboxylase. J Biol Chem 268, 8735-42. Jie, K. S., Hamulyak, K., Gijsbers, B. L., Roumen, F. J., and Vermeer, C. (1992). Serum osteocalcin as a marker for vitamin K-status in pregnant women and their newborn babies. Thromb Haemost 68, 388-91. Soute, B. A., Groenen-van Dooren, M. M., Holmgren, A., Lundstrom, J., and Vermeer, C. (1992). Stimulation of the dithiol-dependent reductases in the vitamin K cycle by the thioredoxin system. Strong synergistic effects with protein disulphide-isomerase. Biochem J 281, 255-9. Soute, B. A., Ulrich, M. M., Watson, A. D., Maddison, J. E., Ebberink, R. H., and Vermeer, C. (1992). Congenital deficiency of all vitamin K-dependent blood coagulation factors due to a defective vitamin K-dependent carboxylase in Devon Rex cats. Thromb Haemost 68, 521-5. Vermeer, C., Knapen, M. H., Jie, K. S., and Grobbee, D. E. (1992). Physiological importance of extra-hepatic vitamin K-dependent carboxylation reactions. Ann N Y Acad Sci 669, 21-31; discussion 31-3. Soute, B. A., Bude, R., and Vermeer, C. (1991). Vitamin K-dependent carboxylation of poly-L-glutamate. Biochim Biophys Acta 1073, 434-6. Vermeer, C., and Hamulyak, K. (1991). Pathophysiology of vitamin K-deficiency and oral anticoagulants. Thromb Haemost 66, 153-9. Gijsbers, B. L., van Haarlem, L. J., Soute, B. A., Ebberink, R. H., and Vermeer, C. (1990). Characterization of a Gla-containing protein from calcified human atherosclerotic plaques. Arteriosclerosis 10, 991-5. Soute, B. A., Acher, F., Azerad, R., and Vermeer, C. (1990). Vitamin K-dependent carboxylase: effect of ammonium sulfate on substrate carboxylation and on inhibition by stereospecific substrate analogs. Biochim Biophys Acta 1034, 11-6. Vermeer, C. (1990). Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase. Biochem J 266, 625-36. Wu, S. M., Soute, B. A., Vermeer, C., and Stafford, D. W. (1990). In vitro gamma-carboxylation of a 59-residue recombinant peptide including the propeptide and the gamma-carboxyglutamic acid domain of coagulation factor IX. Effect of mutations near the propeptide cleavage site. J Biol Chem 265, 13124-9.
Publication list 1980-1989 of Associate Professor Dr. Cees Vermeer
  1. Hubbard, B. R., Ulrich, M. M., Jacobs, M., Vermeer, C., Walsh, C., Furie, B., and Furie, B. C. (1989). Vitamin K-dependent carboxylase: affinity purification from bovine liver by using a synthetic propeptide containing the gamma- carboxylation recognition site. Proc Natl Acad Sci U S A 86, 6893-7.Knapen, M. H., Hamulyak, K., and Vermeer, C. (1989). The effect of vitamin K supplementation on circulating osteocalcin (bone Gla protein) and urinary calcium excretion. Ann Intern Med 111, 1001-5.Soute, B. A., Balland, A., Faure, T., de la Salle, H., and Vermeer, C. (1989). In vitro carboxylation of a blood coagulation factor IX precursor produced by recombinant-DNA technology. Thromb Haemost 61, 238-42.Soute, B. A., Bude, R., Buitenhuis, H., and Vermeer, C. (1989). Vitamin K-dependent carboxylase: minimized escape of CO2 from solution may prolong linearity of the reaction rate. Anal Biochem 182, 207-11.Vermeulen, A. H., Vermeer, C., and Bosman, F. T. (1989). Histochemical detection of osteocalcin in normal and pathological human bone. J Histochem Cytochem 37, 1503-8.de Boer-van den Berg, M., Thijssen, H. H., and Vermeer, C. (1988). The in vivo effects of oral anticoagulants in man: comparison between liver and non-hepatic tissues. Thromb Haemost 59, 147-50.Soute, B. A., Ulrich, M. M., Knapen, M. H., van Haarlem, L. J., and Vermeer, C. (1988). The quantification of gammacarboxyglutamic acid residues in plasma- osteocalcin. Calcif Tissue Int 43, 184-8.Ulrich, M. M., Furie, B., Jacobs, M. R., Vermeer, C., and Furie, B. C. (1988). Vitamin K-dependent carboxylation. A synthetic peptide based upon the gamma-carboxylation recognition site sequence of the prothrombin propeptide is an active substrate for the carboxylase in vitro. J Biol Chem 263, 9697-702.Ulrich, M. M., Knapen, M. H., Herrmann-Erlee, M. P., and Vermeer, C. (1988). Vitamin K is no antagonist for the action of warfarin in rat osteosarcoma UMR 106. Thromb Res 50, 27-32.van Haarlem, L. J., Knapen, M. H., Hamulyak, K., and Vermeer, C. (1988). Circulating osteocalcin during oral anticoagulant therapy. Thromb Haemost 60, 79-82.Vermeer, C., Soute, B. A., Aalten, M., Knapen, M. H., and Thijssen, H. H. (1988). Vitamin K reductases in normal and in warfarin-resistant rats. Biochem Pharmacol 37, 2876-8.de Boer-van den Berg, M. A., Uitendaal, M. P., and Vermeer, C. (1987). Direct measurement of vitamin K-dependent enzymes in various isolated and cultured tumor and non-tumor cells. Mol Cell Biochem 75, 71-6.Hamulyak, K., de Boer-van den Berg, M. A., Thijssen, H. H., Hemker, H. C., and Vermeer, C. (1987). The placental transport of [3H]vitamin K1 in rats. Br J Haematol 65, 335-8.Hesse, C. J., v.d. Bemd, A., Vermeer, C., Jutte, N. H., Hendriks, G. F., and Weimar, W. (1987). An accurate, simple, and rapid 125I-cyclosporine assay. Transplant Proc 19, 4025-6. Johan, L., van Haarlem, M., Soute, B. A., and Vermeer, C. (1987). Vitamin K-dependent carboxylase. Possible role for thioredoxin in the reduction of vitamin K metabolites in liver. FEBS Lett 222, 353-7. Soute, B. A., Ulrich, M. M., and Vermeer, C. (1987). Vitamin K-dependent carboxylase: increased efficiency of the carboxylation reaction. Thromb Haemost 57, 77-81. Ulrich, M. M., Perizonius, W. R., Spoor, C. F., Sandberg, P., and Vermeer, C. (1987). Extraction of osteocalcin from fossil bones and teeth. Biochem Biophys Res Commun 149, 712-9. Ulrich, M. M., Soute, B. A., van Haarlem, L. J., and Vermeer, C. (1987). Substrate recognition by vitamin K-dependent carboxylase. Thromb Haemost 57, 17-9. van de Loo, P. G., Soute, B. A., van Haarlem, L. J., and Vermeer, C. (1987). The effect of Gla-containing proteins on the precipitation of insoluble salts. Biochem Biophys Res Commun 142, 113-9. Haarlem, L. J., Ulrich, M. M., Hemker, H. C., Soute, B. A., and Vermeer, C. (1987). Isolation and partial characterization of a vitamin K-dependent carboxylase from bovine aortae. Biochem J 245, 251-5. de Boer-van den Berg, M. A., Thijssen, H. H., and Vermeer, C. (1986). The in vivo effects of acenocoumarol, phenprocoumon and warfarin on vitamin K epoxide reductase and vitamin K-dependent carboxylase in various tissues of the rat. Biochim Biophys Acta 884, 150-7. de Boer-van den Berg, M. A., Verstijnen, C. P., and Vermeer, C. (1986). Vitamin K-dependent carboxylase in skin. J Invest Dermatol 87, 377-80. Pezzi, L., Gerna, M., Roncaglioni, M. C., Vermeer, C., and Donati, M. B. (1986). Increased susceptibility to the anticoagulant effect of warfarin in mice bearing the Lewis lung carcinoma. Role of vitamin K deficiency. Biochem Pharmacol 35, 3239-42. Roncaglioni, M. C., Dalessandro, A. P., Casali, B., Vermeer, C., and Donati, M. B. (1986). gamma-Glutamyl carboxylase activity in experimental tumor tissues: a biochemical basis for vitamin K dependence of cancer procoagulant. Haemostasis 16, 295-9. Roncaglioni, M. C., Ulrich, M. M., Muller, A. D., Soute, B. A., de Boer-van den Berg, M. A., and Vermeer, C. (1986). The vitamin K-antagonism of salicylate and warfarin. Thromb Res 42, 727-36. Vermeer, C. (1986). Comparison between hepatic and nonhepatic vitamin K-dependent carboxylase. Haemostasis 16, 239-45. Vermeer, C., Soute, B. A., Ulrich, M. M., and van de Loo, P. G. (1986). Vitamin K and the urogenital tract. Haemostasis 16, 246-57. de Boer-van den Berg, M. A., Ulrich, M. M., Hemker, H. C., Soute, B. A., and Vermeer, C. (1985). Vitamin K-dependent carboxylase: the carboxylation of exogenous substrates in different systems. Biochim Biophys Acta 831, 94-8. Hamulyak, K., and Vermeer, C. (1985). Osteocalcin: a vitamin K-dependent protein in bone. Neth J Med 28, 305-6. Soute, B. A., Muller-Esterl, W., de Boer-van den Berg, M. A., Ulrich, M., and Vermeer, C. (1985). Discovery of a gamma-carboxyglutamic acid-containing protein in human spermatozoa. FEBS Lett 190, 137-41. Ulrich, M. M., Soute, B. A., de Boer-van den Berg, M. A., and Vermeer, C. (1985). Isoenzymes of vitamin-K-dependent carboxylase. Biochim Biophys Acta 830, 105-8. Vermeer, C. (1985). [The biochemistry of vitamin K]. Ned Tijdschr Geneeskd 129, 780-2. Vermeer, C., and De Boer-Van den Berg, M. A. (1985). Vitamin K-dependent carboxylase. Haematologia 18, 71-97. Soute, B. A., de Boer-v.d. Berg, M. A., and Vermeer, C. (1984). The separation of bovine prothrombin and descarboxyprothrombin by high- performance liquid chromatography. Anal Biochem 137, 227-9. Vermeer, C. (1984). The binding of Gla-containing proteins to phospholipids. FEBS Lett 173, 169-72. Vermeer, C. (1984). The vitamin K-dependent carboxylation reaction. Mol Cell Biochem 61, 17-35. Vermeer, C., Soute, B. A., Hendrix, H., and de Boer-van den Berg, M. A. (1984). Decarboxylated bone Gla-protein as a substrate for hepatic vitamin K- dependent carboxylase. FEBS Lett 165, 16-20. Vermeer, C., Soute, B. A., Ulrich, M., Hamulyak, K., and De Boer-van den Berg, M. A. (1984). The vitamin K-dependent carboxylation of proteins. Biochem Soc Trans 12, 922-4. De Metz, M., Soute, B. A., Hemker, H. C., and Vermeer, C. (1983). Stimulation of the vitamin K-dependent carboxylase from bovine liver. Biochem J 209, 719-24. Roncaglioni, M. C., Soute, B. A., de Boer-v.d. Berg, M. A., and Vermeer, C. (1983). Warfarin-induced accumulation of vitamin K-dependent proteins. Comparison between hepatic and non-hepatic tissues. Biochem Biophys Res Commun 114, 991-7. de Metz, M., Soute, B. A., Hemker, H. C., Fokkens, R., Lugtenburg, J., and Vermeer, C. (1982). Studies on the mechanism of the vitamin K-dependent carboxylation reaction. Carboxylation without the concurrent formation of vitamin K 2,3-epoxide. J Biol Chem 257, 5326-9. De Metz, M., Soute, B. A., Hemker, H. C., and Vermeer, C. (1982). The inhibition of vitamin K-dependent carboxylase by cyanide. FEBS Lett 137, 253-6. Soute, B. A., de Metz, M., and Vermeer, C. (1982). Characteristics of vitamin K-dependent carboxylating systems from human liver and placenta. FEBS Lett 146, 365-8. Vermeer, C. (1982). [Side effects of oral anticoagulant therapy? (letter)]. Ned Tijdschr Geneeskd 126, 2394. Vermeer, C., Hendrix, H., and Daemen, M. (1982). Vitamin K-dependent carboxylases from non-hepatic tissues. FEBS Lett 148, 317-20. Vermeer, C., Soute, B. A., De Metz, M., and Hemker, H. C. (1982). A comparison between vitamin K-dependent carboxylase from normal and warfarin-treated cows. Biochim Biophys Acta 714, 361-5. Vermeer, C., and Ulrich, M. (1982). Vitamin K-dependent carboxylase in horse liver, spleen and kidney. Thromb Res 28, 171-7. de Metz, M., Vermeer, C., Soute, B. A., and Hemker, H. C. (1981). Identification of phospholipid as an essential part of bovine vitamin K- dependent carboxylase. J Biol Chem 256, 10843-6. de Metz, M., Vermeer, C., Soute, B. A., van Scharrenburg, G. J., Slotboom, A. J., and Hemker, H. C. (1981). Partial purification of bovine liver vitamin K-dependent carboxylase by immunospecific adsorption onto antifactor X. FEBS Lett 123, 215-8. Soute, B. A., Vermeer, C., De Metz, M., Hemker, H. C., and Lijnen, H. R. (1981). In vitro prothrombin synthesis from a purified precursor protein. III. Preparation of an acid-soluble substrate for vitamin K-dependent carboxylase by limited proteolysis of bovine descarboxyprothrombin. Biochim Biophys Acta 676, 101-7.
Publication list 1975-1979 of Associate Professor Dr. Cees Vermeer
  1. Hemker, H. C., Vermeer, C., and Govers-Riemslag, J. (1977). Kinetic aspects of the interaction of blood clotting enzymes. VII. The relation between clotting time and prothrombin concentration. Thromb Haemost 37, 81-5.
  2. Kirchhof, B. R., Muller, A. D., Vermeer, C., and Hemker, H. C. (1979). Control of anticoagulant therapy with a chromogenic substrate. Haemostasis 8, 1-7.
  3. Kirchhof, B. R., Vermeer, C., and Hemker, H. C. (1978). The determination of prothrombin using synthetic chromogenic substrates; choice of a suitable activator. Thromb Res 13, 219-32.
  4. Vermeer, C., Govers-Riemslag, J. W., Soute, B. A., Lindhout, M. J., Kop, J., and Hemker, H. C. (1978). The role of blood clotting factor V in the conversion of prothrombin and a decarboxy prothrombin into thrombin. Biochim Biophys Acta 538, 521-33.
  5. Vermeer, C., Hemker, H. C., and Soute, B. A. (1977). The synthesis of prothrombin from its precursor protein. Bibl Haematol 44, 54-60.
  6. Vermeer, C., Soute, B. A., Ates, G., and Brummelhuis, H. G. (1976). Contribution to the optimal use of human blood. VII. Increase of the yield of factor VIII in four-donor cryoprecipitate by an improved processing of blood and plasma. Vox Sang 30, 1-22.
  7. Vermeer, C., Soute, B. A., Ates, G., Hellings, J. A., and Brummelhuis, H. G. (1976). Contributions to the optimal use of human blood. VIII. Stability of blood coagulation factor VII during collection and storage of whole blood and plasma. Vox Sang 31, 55-67.
  8. Vermeer, C., Soute, B. A., and Brummelhuis, H. G. (1975). Proceedings: Improvement of the preparation of factor VIII concentrates. Thromb Diath Haemorrh 34, 589-90.
  9. Vermeer, C., Soute, B. A., Govers-Riemslag, J., and Hemker, H. C. (1976). In vitro prothrombin synthesis from a purified precursor protein. I. Development of a bovine liver cell-free system. Biochim Biophys Acta 444, 926-30.
  10. Vermeer, C., Soute, B. A., and Hemker, H. C. (1979). A coagulation reagent completely devoid of factor X; relation between clotting time and concentration of factor X. Thromb Res 14, 679-85.
  11. Vermeer, C., Soute, B. A., and Hemker, H. C. (1978). Improvements of the method for the preparation of an artificial prothrombin reagent. Thromb Res 12, 713-6.
  12. Vermeer, C., Soute, B. A., and Hemker, H. C. (1978). In vitro prothrombin synthesis from a purified precursor protein. II. Partial purification of bovine carboxylase. Biochim Biophys Acta 523, 494-505.
  13. Vermeer, C., Soute, B. A., and Hemker, H. C. (1977). A new method for the preparation of artificial factor II reagents from normal human and bovine plasma. Thromb Res 10, 495-507.
  14. Vermeer, C., Soute, B. A., and Hemker, H. C. (1978). A quick method for the determination of decarboxyfactor X. Thromb Res 12, 1071-8.

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