Vitak, Maastricht University
Innovative Medical Devices
Innovation & Research
MGP Center
Human Trial Center: ICHIS
Education
Measurements & Resources

2006-2010

  1. Le Boulanger, G., Labrèze, C., Croué, A., Schurgers, L.J., Chassaing, N., Wittkampf, T., Rutsch, F., Martin, L. An unusual severe case of pseudoxanthoma elasticum presenting as generalized arterial calcification of infancy. Am. J. Med. Genet. 152A (2010) 118-123.
  2. Shroff, R.C., McNair, R., Skepper, J.N., Figg, N., Schurgers, L.J., Deanfield, J., Rees, L., Shananhan, C.M. Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification. J. Am. Soc. Nephrol. 21 (2010) 103-112.
  3. Ueland, T., Fougner, S.L., Godang, K., Lekva, T., Schurgers, L.J., Scholz, H., Halvorsen, B., Schreiner, T., Aukrust, P., Bollerslev, J. Associations between body composition, circulating interleukin-1 receptor antagonist, osteocalcin and insulin metabolism in active acromegaly. J Clin Endocrinol Metab. 95 (2010) 361-368.
  4. Schlieper, G., Grotemeyer, D., Aretz, A., Schurgers, L.J., Krüger, T., Rehbein, H., Weirich, T.E., Westenfeld, R., Brandenburg, V.M., Eitner, F., Mayer, J., Floege, J., Sandmann, W., Ketteler, M. Analysis of Calcifications in Patients with Coral Reef Aorta. Ann. Vasc. Surg. 24 (2010) 408-414.
  5. Schurgers, L.J., Barreto, D.V., Liaboeuf, S., Barreto, F.C., Renard, C., Magdeleyns, E.J., Vermeer, C., Choukroun, G., Massy, Z.A. The circulating inactive form of matrix Gla protein is a surrogate marker for vascular calcification in chronic kidney disease: a preliminary report. Clin. J. Am. Soc. Nephrol. 5 (2010) 568-575.
  6. Schurgers, L.J., Vermeer. C. Matrix Gla-Proteine: een vitamine K-afhankelijke remmer van vaatverkalking. Tromnibus 38 (2010) 11-16.
  7. Parker BD, Schurgers LJ, Vermeer C, Schiller NB, Whooley MA, Ix JH. The Association of Uncarboxylated Matrix Gla Protein with Mitral Annular Calcification Differs by Diabetes Status: The Heart and Soul Study. Atherosclerosis 210 (2010) 320-325.
  8. Rennenberg, R.J.M.W., de Leeuw, P.W., Kessels, A.G.H., Schurgers, L.J., Vermeer, C., van Engelshoven, J.M.A., Kemerink, G.J., Kroon, A.A. Calcium scores and matrix gla-protein levels: association with vitamin K status. Eur. J. Clin. Invest. 40 (2010) 344-349.
  9. Parker, B.D., Schurgers, L.J., Brandenburg, V.M., Christenson, R.H., Vermeer, C. Ketteler, M., Shlipak, M.G., Whooley, M.A., Ix, J.H. FGF-23, Matrix Gla Protein, Fetuin-A and Mortality in Persons with Coronary Heart Disease: The Heart and Soul Study. Ann. Int. Med. 152 (2010) 640-648.
  10. C. Vermeer. Diagnostic assay for human matrix Gla-protein and its use as a biomarker. US Patent 7,700,296 B2. Date of approval: April 20, 2010.
  11. Vanakker, O.M., Martin, L., Schurgers, L.J., Gheduzzi, D., Vermeer, C., Pasquali-Ronchetti, I., Coucke, P.J., De Paepe, A. Low serum vitamin K in PXE results in defective carboxylation of mineralization inhibitors similar to the GGCX mutations in the PXE-like syndrome. Lab. Invest. 90 (2010) 895-905.
  12. Rennenberg R.J.M.W., van Varik, B.J., Schurgers, L.J., Hamulyak, K., ten Cate, H., Leiner, T., Vermeer, C., de Leeuw, P.W., Kroon, A.A. Chronic coumarin treatment is associated with increased extra-coronary arterial calcification in humans. Blood 115 (2010) 5121-5123.
  13. Wallin, R., Schurgers, L.J., Loeser, R.F. Biosynthesis of the vitamin K-dependent matrix Gla protein (MGP) in chondrocytes: a fetuin-MGP protein complex is assembled in vesicles shed from normal but not from osteoarthitic chondrocytes. Osteoarthritis Cartilage 18 (2010) 1096-1103.
  14. Cranenburg E.C.M., Koos, R., Schurgers, L.J., Magdeleyns, E., Schoonbrood, T.H.M., Landewe, R., Brandenburg, V.M., Bekers, O., Vermeer, C. Characterization and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thromb. Haemostas. 104 (2010) 811-822.
  15. Ueland, T., Gullestad, L., Dahl, C.P., Aukrust, P., Aakhus, S., Solberg, O.G., Vermeer, C., Schurgers, L.J. Undercarboxylated matrix gla protein is associated with development of heart failure in symptomatic aortic stenosis. J. Int. Med. 268 (2010) 483-492.
  16. Cosemans, J.M.E.M., Munnix, I.C.A., Schurgers, L.J., Schols, S.E.M., Angelillo-Scherrer, A., Hoylaerts, M., Carmeliet, P., Heemskerk, J.W.M. Roles of human and mouse Gas6 and Gas6 receptors in the formation and stabilization of thrombi. J. Thromb. Haemostas 8 (2010) 1797-1808.
  17. Rennenberg, R.J., Schurgers, L.J., Kroon, A.A., Stehouwer, C.D. Arterial calcifications. J. Cell Mol. Med. 14 (2010) 2203-2210.
  18. van Hasselt, P.M., de Vries, W., de Vries, E., Kok, K., Cranenburg, E.C.M., de Koning, T.J., Schurgers, L.J., Verkade, H.J., Houwen, R.H.J. Hydrolysed formula is a risk factor for vitamin K deficiency in infants with unrecognised cholestasis. J. Pediatr. Gastroenterol. Nutr. 51 (2010) 773-776.
  19. Hristova, M., van Beek, C., Schurgers, L.J., Lanske, B., Danziger, J. Rapidly progressive severe vascular calcification sparing the kidney allograft following warfarin initiation. Am. J. Kidney Dis. 56 (2010), 1158-1162.
  20. Cranenburg, E.C.M., Brandenburg, V.M., Westenfeld, R., Krueger, T., Stenger, M., Vermeer, C., Schurgers, L.J., Ketteler, M. Matrix-Gla Protein (MGP) is associated with the amount of coronary artery calcification in HD patients as assessed by MSCT Agatston score. Thromb. Haemostas. 101 (2009) 359-366.
  21. Li, Q., Schurgers, L.J., Smithm A.C., Tsokos, M., Uitto, J., Cowen, E.W. Co-existent Pseudoxanthoma Elasticum and vitamin K-dependent coagulation factor deficiency. Compound heterozygosity for mutations in the GGCX gene. Am. J. Pathol. 174 (2009) 534-540.
  22. Li, Q., Grange, D.K., Armstrong, N.L., Whelan, A.J., Hurley, M.Y., Rishavy, M., Hallgren, K., Berkner, K.L., Schurgers, L.J., Jiang, Q., Uitto, J. Mutations in the GGCX and ABCC6 Genes in a Family with Pseudoxanthoma Elasticum-like Phenotypes. J. Invest. Dermatol. 129 (2009) 553-563.
  23. Koos, R.,Kühl, H.P., Brandenburg, V., Mahnken, A.H., Stanzel, S., Flöge, J., Kelm, M., Vermeer, C., Schurgers, L.J. Relation of circulating matrix-gla-protein and anticoagulation status in patients with aortic valve calcification. Thromb. Haemostas. 101 (2009) 706-713.
  24. Krueger, T., Westenfeld, R., Schurgers, L., Brandenburg, V. Coagulation meets calcification: the vitamin K system. Int. J. Artif. Organs 32 (2009) 67-74.
  25. Schlieper, G., Brandenburg, V., Djuric, Z., Damjanovic, T., Markovic, N., Schurgers, L.J., Krüger, T., Westenfeld, R., Ackermann, D., Haselhuhn, A., Dimkovic, S., Ketteler, M., Floege, J., Dimkovic, N. Risk factors for cardiovascular calcifications in non-diabetic caucasian haemodialysis patients. Kidney Blood Press. Res. 32 (2009) 161-168.
  26. Rennenberg, R.J., Kessels, A.G., Schurgers, L.J., van Engelshoven, J.M., de Leeuw, P.W., Kroon, A.A. Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis. Vasc. Health Risk Manag. 5 (2009) 185-197.
  27. Westenfeld, R., Schäfer, C., Krüger, T., Haarmann, C., Schurgers, L.J., Reutelingsperger, C., Ivanovski, O., Druecke, T., Massy, Z.A., Ketteler, M., Floege, J., Jahnen-Dechent, W. Fetuin-A protects against atherosclerotic calcifications in mice with renal failure. J. Am. Soc. Nephrol. 20 (2009) 1264-1274.
  28. Krueger, T., Westenfeld, R., Ketteler, M., Schurgers, L.J., Floege, J. Vitamin K deficiency in CKD patients: a modifiable risk factor for vascular calcification? Kidney Int. 76 (2009) 18-22.
  29. Parker, B.D., Ix, J.H., Cranenburg, E.C.M., Vermeer, C., Whooley, M.A., Schurgers, L.J. Association of kidney function and uncarboxylated Matrix Gla Protein: data from the Heart and Soul Study. Nephrol. Dial. Transplant. 24 (2009) 2095-2101.
  30. Mertsch, S., Schurgers, L.J., Weber, K., Paulus, W., Senner, V. Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastoma. BMC Cancer 9 (2009) 302.
  31. Van Summeren, M.H.J., Braam, L.A.J.L.M., Lilien, M.R., Schurgers, L.J., Kuis, W., Vermeer, C. The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children Brit. J. Nutr. 102 (2009) 1171-1178.
  32. Le Boulanger, G., Labrèze, C., Croué, A., Schurgers, L.J., Chassaing, N., Wittkampf, T., Rutsch, F., Martin, L. An unusual severe case of pseudoxanthoma elasticum presenting as generalized arterial calcification of infancy. Am. J.Med. Genet. 152A (2010) 118-123.
  33. Card, D., Shearer, M.J., Schurgers, L.J., Harrington, D.J. The external quality assurance of phylloquinone (vitamin K1) analysis in human serum. Biomed. Chromatogr. 23 (2009) 1276-1282.
  34. Schurgers, L.J., Vermeer C. Vitamine K: meer dan alleen een cofactor voor stolling. Tromnibus 37 (2009) 49-54. Patent: Vermeer, C. Anti-thrombotic effects of vitamin K. International filing date: 17.09.2009.
  35. Van Summeren, M.J.H., Spliet, W.G.M., van Royen-Kerkhof, A., Vermeer, C., Lilien, M., Kuis, W., Schurgers, L.J. Calcinosis in juvenile dermatomyositis: a possible role for the vitamin K-dependent protein MGP. Rheumatol. 47 (2008) 267-271.
  36. Golledge, J., Jayalath, R., Oliver, L., Parr, A., Schurgers, L., Clancy, P. Relationship between CT anthropometric measurements, adipokines and abnormal aortic calcification. Atherosclerosis 197 (2008) 428-432.
  37. Cranenburg, E.C.M., Vermeer, C., Koos, R., Boumans, M.-L., Kwaijtaal, M., Ketteler, M., Brandenburg, V., Schurgers, L.J. The circulating inactive form of Matrix Gla Protein (ucMGP) as a biomarker for cardiovascular disease. J. Vasc. Res. 45 (2008) 427-436.
  38. Van Summeren, M.J.H., Vermeer, C., Engelbert, R.H.H., Schurgers, L.J., Takken, T., Fischer, K., Kuis, W. Extremes in vitamin K status of bone are related to bone ultrasound properties in children with juvenile idiopathic arthritis. Clin. Exptl. Rheumatol. 26 (2008) 484-491.
  39. Van Summeren, M.H.J., Hameleers, J., Schurgers, L.J., Hoeks, A.P.G., Uiterwaal, C.S.P.M., Krüger, T., Vermeer, C., Kuis, W., Lilien, M.R. Circulating levels of calcification inhibitors and vascular properties in children after renal transplantation. Pediatr. Nephrol. 23 (2008) 985-993.
  40. Wallin, R., Schurgers, L.J., Wajih, N. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. Thromb. Res. 122 (2008) 411-417.
  41. Van Summeren, M.J.H., van Coeverden, S.C.C.M., Schurgers, L.J., Braam, L.A.J.L.M., Noirt, F., Uiterwaal, C., Kuis, W., Vermeer, C. Vitamin K status is associated with childhood bone mineral content. Brit. J. Nutr 100 (2008) 852-858.
  42. Shroff, R.C., Shah, V., Hiorns, M.P., Schoppet, M., Hofbauer, L.C., Hawa, G., Schurgers, L.J., Singhal, A., Merryweather, I., Brogan, P., Shanahan, C., Deanfield, J., Rees, L. The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not Matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis. Nephrol. Dial. Transplant. 23 (2008) 3262-3271.
  43. Schurgers, L.J., Cranenburg, E., Vermeer, C. Matrix Gla-protein: the calcification inhibitor in need of vitamin K. Thromb. Haemostas. 100 (2008) 593-603.
  44. Vermeer, C. Vitamin K, Matrix Gla-protein and vascular calcification: treatment options of vascular complications in renal disease. Wiener Medizinische Wochenschrift Skriptum 5/11 (2008) 12-13.
  45. Shroff, R.C., McNair, R., Figg, N., Skepper, J.N., Schurgers, L.J., Gupta, A., Hiorns, M., Donald, A.E., Deanfield, J., Rees, L., Shanahan, C.M. Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation. 118 (2008) 1748-1757.
  46. Vanschoonbeek, K., Wouters, K., van der Meijden, P.E.J., van Gorp, P.J., Feijge, M.A.H., Herfs, M., Schurgers, L.J., Hofker,M.H., de Maat, M.P.M., Heemskerk, J.W.M. Anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in APOE2 knock-in mice. Arterioscler. Thromb. Vasc. Biol. 28 (2008) 2023-2029.
  47. Rennenberg, R.J.M.W., Schurgers, L.J., Vermeer, C., Houben, A.J.H.M., de Leeuw, P.W., Kroon, A.A. Renal handling of matrix gla-protein in humans with moderate to severe hypertension. Hypertension Research 31 (2008) 1745-1751.
  48. Schlieper, G., Krüger, T., Djuric, Z., Damjanovic, T., Markovic, N., Schurgers, L.J., Brandenburg, V., Westenfeld, R., Dimkovic, S., Ketteler, M., Grootendorst, D.C., Dekker, F., Floege, J., Dimkovic, N. Vascular access calcification predicts mortality in hemodialysis patients. Kidney International 74 (2008) 1582-1587.
  49. Bügel, S., Sorensen, A.D., Hels, O., Vermeer, C., Jakobsen, J., Flynn, A., Molgaard, C., Cashman, K. Effect of vitamin K on bone markers in postmenopausal women. EurNutr. 97 (2007) 373-380.
  50. Van Summeren, C.M.J.H., Braam, L., Noirt, F., Kuis, W., Vermeer, C. Pronounced elevation of undercarboxylated osteocalcin in healthy children. Ped. Res. 61 (2007) 366-370.
  51. Schurgers, L.J., Spronk, H.M.H., Soute, B.A.M., Schiffers, P.M., DeMey, J.G.R., Vermeer, C. Regression of arterial medial calcification after high intake of vitamin K. Blood 18 (2007) 2823-2831.
  52. Knapen, M.H.J., Schurgers, L.J., Vermeer, C. Vitamin K2 supplementation improves bone geometry and bone strength indices in postmenopausal women. Osteoporosis International 18 (2007) 963-972.
  53. Schurgers, L.J., Teunissen, K.J.F., Hamulyák, K., Knapen, M.H.J., Vik, H., Vermeer, C. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood 109 (2007) 3279-3283.
  54. Stafford, D.W., Roberts, H., Vermeer, C. Vitamin K supplementation during oral anticoagulation: cautions. Blood 109 (2007) 3607-3608.
  55. Schurgers, L.J., Knapen, M.H.J., Vermeer, C. Vitamin K2 improves bone strength in postmenopausal women. Elsevier International Congress Series 1297 (2007) 179-187.
  56. Cranenburg, E.C.M., Schurgers, L.J., Vermeer, C. Vitamin K, the coagulation vitamin that became omnipotent. Thromb. Haemostas. 98 (2007) 120-125.
  57. Cario-Toumaniantz, C., Boularan, C., Schurgers, L.J., Heymann, M.F., Le Cunff, M., Léger, J., Loirand, G., Pacaud, P. Identification of differentially expressed genes in human varicose veins: involvement of Matrix Gla-Protein in extracellular matrix. J Vasc. Res. 44 (2007) 444-459.
  58. Göritz, C., Thiebaut, R., Tessier, L.-H., Nieweg, K., Moehle, C., Buard, I., Dupont, J.-L., Schurgers, L.J., Schmitz, G., Pfrieger, F.W. Glia-induced neuronal differentiation by transcriptional regulation. Glia 55 (2007) 1108-1122.
  59. Hermans, M.M.H., Vermeer, C., Kooman, J.P., Brandenburg, V., Ketteler, M, Gladziwa, U., RensmaP.L., Leunissen, K.M.L., Schurgers, L.J., Undercarboxylated matrix-Gla protein levels are decreased in dialysis patients and related to parameters of calcium-phosphate metabolism and aortic augmentation index. Blood Purification 25 (2007) 395-401.
  60. Gheduzzi, D., Boraldi, F., Giulia, A., DeVincenzi Chiara, P., Schurgers, L.J., Vermeer, C., Quaglino, D., Pasquali Ronchetti, I. Matrix Gla Protein (MGP) in Pseudoxanthoma Elasticum (PXE) and in genetic disorders with PXE-like clinical manifestations. Lab Invest. 87 (2007) 998-1008.
  61. Vermeer, C. Diagnostic assay for human Matrix Gla-Protein and its use as a biomarker. EU Patent Nr. 1190259. Eur. Patent Bull. 46 (2007) 14 november
  62. Li, Q., Jiang, Q., Schurgers, L.J., Uitto, J. Pseudoxanthoma elasticum: reduced gammaglutamyl carboxylation of matrix gla protein in a mouse model (Abvv6-/-). Biochem. Biophys. Res. Commun. 364 (2007) 208-213.
  63. Schurgers, L.J., Spronk, H.M.H., Soute, B.A.M., Vermeer, C., Weissberg, P.L., Shanahan, C.M., Proudfoot, D. Posttranslational modifications regulate matrix Gla protein (MGP) function: importance for inhibition of vascular smooth muscle cell calcification. J. Thromb. Haemostas. 5 (2007) 2503-2511.
  64. Vermeer, C., Schurgers, L.J. Importance of vitamin K for bone health. In: Bone health and vascular health in chronic inflammation. Ed.: Capraru, C. ISBN 978-973-35-2317-8 (2007) pp 10-14.
  65. Vermeer, C., Schurgers, L.J. Importance of vitamin K for vascular health. In: Bone health and vascular health in chronic inflammation. Ed.: Capraru, C. ISBN 978-973-35-2317-8 (2007) pp 59-63.
  66. Van Langendonckt A, Punyadeera C, Kamps R, Dunselman G, Schurgers LJ, Squifflet J, Donnez J, Groothuis P. Identification of novel antigens in blood vessels in rectovaginal endometriosis. Mol. Hum. Reprod. 13 (2007) 875-886.
  67. Janzen, J., Schurgers, L.J., Vermeer, C., Joris, F., Musy, J.-.P, Schmidli, J. Mediakalzifikationen in einem Aneurysma des Arcus aortae. Perfusion 19 (2006) 237-241.
  68. Panis, B., Vermeer, C., van Kroonenberg, M.J., Nieman, F.H., Menheere, P.P., Spaapen, L.J., Rubio-Gozalbo, M.E. Effect of calcium, vitamins K(1) and D(3) on bone in galactosemia. Bone 39 (2006) 1123-1129.
  69. Willems, H.P., den Heijer, M., Gerrits, W.B., Schurgers, L.J., Havekes, M., Blom H.J., Bos, G.M. Oral anticoagulant treatment with coumarin derivatives does not influence plasma homocysteine concentration. Eur. J. Intern. Med. 17 (2006) 120-124.
  70. Johnson, J.S., Soute, B.A.M., Olver, C.S., Baker, D.C. Defective gamma-glutamyl carboxylase activity and bleeding in Rambouillet sheep. Vet. Pathol. 43 (2006) 726-732.
  71. Thijssen, H.H.W., Vervoort, L.M.T., Schurgers, L.J., Shearer, M.J. Menadione is a metabolite of K-vitamins; an explanation of the route of conversion of phylloquinone into menaquinone-4. Brit. J. Nutr. 95 (2006) 260-266.