Vitak, Maastricht University
Innovative Medical Devices
Innovation & Research
MGP Center
Human Trial Center: ICHIS
Measurements & Resources


  1. Ayşe Y. Demir, Patrick G. Groothuis, Gerard A. J. Dunselman, Leon J. Schurgers, Johannes L. H. Evers, Anton F. P. M. de Goeij. Molecular characterization of soluble factors from human menstrual effluent that induce epithelial to mesenchymal transitions in mesothelial cells. Cell Tissue Res. 2005 Aug 5;:1-13 (ipf 2.67)
  2. Schurgers, L.J., Teunissen, K.J.F., Knapen, M.H.J., Kwaijtaal, M., van Diest, R., Appels, A., Reutelingsperger, C.P., Cleutjens, J.P.M., Vermeer, C. (2005). Novel conformation-specific antibodies against matrix Gla-protein: undercarboxylated matrix Gla protein as marker for vascular calcification. Arterioscler. Thromb. Vasc. Biol. 25, 1629-1633.
  3. Vermeer, C., Schurgers, L.J. (2005). Direct testing for deficiencies. Ingredients, Health & Nutrition 8, 10-12.
  4. Schurgers, L.J., Teunissen, K., Knapen, M.H.J., Geusens, P., van der Heijde, D., Kwaijtaal, M., van Diest, R., Ketteler, M., Vermeer, C. (2005). Characteristics and performance of an immunosorbent assay for human matrix Gla-protein (MGP). Clin. Chim. Acta 351, 131-138.
  5. Smith, C.I., Craig, O.E., Prigodich, R.V., Nielsen-Marsh, C.M., Jans, M.M.E., Vermeer, C., Collins, M.J. Diagenesis and survival of osteocalcin in archaeological bone. J. Arch. Sci. 32 (2005) 105-113.
  6. Kobayashi, N., Kitazawa, R., Maeda, S., Schurgers, L.J., Kitazawa, S. (2004). T-138C polymorphism of matrix Gla protein promotor alters its expression but is not directly associated with atherosclerotic vascular calcification. Kobe J. Med. Sci. 50, 1-13.
  7. Vermeer, C., Hamulyák, K. (2004). Vitamin K: lessons from the past. J. Thromb. Haemostas. 2, 2115-2117
  8. Reynolds, J.L., Joannides, A.J., Skepper, J.N., McNair, R., Schurgers, L.J., Proudfoot, D., Weissberg, P.L., Shanahan, C.M. (2004). Vesicle-mediated calcification of human smooth muscle cells in response to changes in extracellular mineral. A mechanism for accelerated vascular calcification in end-stage renal disease. J. Am. Soc. Nephrol. 15, 2857-2867.
  9. Geleijnse, J.M., Vermeer, C., Grobbee, D.E., Pols, H.A.P., Schurgers, L.J., Knapen, M.H.J., van der Meer, I.M., Hofman, A., Witteman, J.C.M. (2004). Dietary intake of vitamin K-2 reduces the risk of cardiac events and aortic atherosclerosis: The Rotterdam Study. J. Nutr. 134, 3100-3105.
  10. Ryan, B.M., Russel, M.G.V.M., Schurgers, L.J., Wichers, M., Sijbrandij, J., Stockbrugger, R.W., Schoon, E. (2004). Effect of antitumour necrosis factor-alpha therapy on bone turnover in patients with Crohn's disease: a prospective study. Alimentary Pharmacology and Therapeutics 20, 851-857.
  11. Thijssen H.H.W., Soute, B.A.M., Vervoort, L.M.T., Claessens, J.G. (2004). Paracetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycle. Thromb. Haemstas. 92, 797-802. Vermeer, C., Braam, L.A.J.L.M. (2004). Increased vitamin K intake may decrease bone loss. Osteoporosis Review 12, 11-14.
  12. Schurgers, L.J., Aebert, H., Vermeer, C., Bültmann, B., Janzen, J. (2004). Oral anticoagulant treatment: friend or foe in cardiovascular disease? Blood 104, 3231-3232.
  13. Schurgers, L.J., Shearer, M.J., Hamulyák, K., Stöcklin, E., Vermeer, C. (2004). Effect of vitamin K on the stability of oral anticoagulant treatment: dose response relationship in healthy subjects. Blood 104, 2682-2689.
  14. Panis, B., Forget, P.Ph., van Kroonenburgh, M.J.P.G., Vermeer, C., Menheere, P.P., Nieman, F.H., Rubio-Gozalbo, M.E. (2004). Bone metabolism in Galactosemia. Bone 35, 982-987.
  15. Thijssen H.H.W, Soute, B.A.M, Vervoort, L.M.T., Claessens, J.G. (2004). Paracetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycle. Thromb. Haemstas. 92, 797-802.
  16. Braam, L., McKeown, N., Jacques, P., Lichtenstein, A., Vermeer, C., Wilson, P., Booth, S. (2004). Dietary phylloquinone intake as a potential marker for heart-healthy dietary pattern in the Framingham Offspring cohort. J. Am. Dietet. Nutr. 104, 1410-1414.
  17. Vermeer, C., Shearer, M.J., Zittermann, A., Bolton-Smith, C., Szulc, P., Hodges, P., Walter, P., Rambeck, W., Stöcklin, E., Weber, P. (2004). Beyond deficiency: potential benefits of increased intakes of vitamin K for bone and vascular health. Eur. J. Nutr. 43, 1-11.
  18. Soute B.A.M., Jin, D.Y., Spronk, H.M.H., Mutucumarana, V., Lin, P.J., Hackeng, T.M., Stafford, D.W., Vermeer, C. (2004). Characteristics of recombinant W501S mutated human γ-glutamyl carboxyase. J. Thromb. Haemostas. 2, 597-604.

    Jono, S., Ikari, Y., Vermeer, C., Dissel, P., Hasegawa, K., Shioi, A., Taniwaki, H., Kizu, A., Nishizawa, Y. Saito, S. (2004). Matrix Gla-protein is associated with coronary artery calcification as assessed by electron-beam computed tomography. Thromb. Haemostas. 91, 790-794.

    Vermeer, C. (2004). Vitamin K and cardiovascular health - what is the optimum? Brit. J. Cardiol. 11, S4-S5.
    Braam, L.A.J.L.M., Hoeks, A.P.G., Brouns, F., Hamulyák, K., Gerichhausen, M.J.W., Vermeer, C. (2004). Beneficial effects of vitamin K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study. Thromb. Haemostas. 91, 373-380.

    Vermeer, C., Braam, L., Knapen,. M., Schurgers, L. (2003). Vitamin K supplementation: a simple way to improve bone and vascular health. Agrofood Industry Hi-Tech 14, 17-20.

    Vermeer, C., Schurgers, L.J., Braam, L.A.J.L.M. (2003). Potential applications of vitamin K-containing products. Nutracos 5, 13-16.

    van Hoorn, J.H.L., Hendriks, J.J.E., Vermeer, C., Forget, P.Ph. (2003). Vitamin K supplementation in cystic fibrosis. Arch. Dis. Child. 88, 974-975.

    Braam, L.A.J.L.M., Knapen, M.H.J., Geusens, P., Brouns, F., Vermeer, C. (2003). Factors affecting bone loss in female endurance athletes: a two-year follow -up study. Am. J. Sports Med. 31, 889-895.

    Spronk, H.M.H., Soute, B.A.M., Schurgers, L.J., De Mey, J.G.R., Vermeer, C. (2003). Tissue-specific utilisation of menaquinone-4 results in prevention of arterial calcification in warfarin-treated rats, J. Vasc. Res. 40, 531-537.

    Mosler, K., von Kries, R., Vermeer, C., Saupe, J., Schmitz, T., Schuster, A. (2003). Assessment of vitamin K deficiency in CF - how much sophistication is useful? J. Cyst. Fibros. 2, 91-96.

    Vermeer, C. (2003). Vitamin K and bone health. Curr. Topics in Nutraceut. Res. 1, 73-84.

    Ketteler, M., Wanner, C., Metzger, T., Bongartz, P., Westenfeld, R., Gladziwa, U., Schurgers, L.J., Vermeer, C., Jahnen-Dechent, W. Floege, J. (2003). Deficiencies of calcium-regulatory proteins in dialysis patients: a novel concept of cardiovascular calcification in uremia. Kidney Int. Suppl. 84, 84-87.

    Braam, L.A.J.L.M., Knapen, M.H.J., Geusens, P., Brouns, F., Hamulyák, K., Gerichhausen, M.J.W., Vermeer, C. (2003). Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age. Calcif. Tissue Int. 73, 21-26.

    Vermeer, C., Braam, L., Schurgers, L. (2002). Vitamin K-enrichment: a new challenge for functional foods that target cardiovascular and bone health. IHN Magazine 5, 12-16.

    Graff, I.E., Waagbø, R., Fivelstad, S., Vermeer, C., Lie, Ø, Lundebye, A.K. (2002). A multivariate study on the effects of vitamin K, vitamin D3, calcium, and water carbon dioxide on growth, bone minerals, vitamin status and health performance in smolting Atlantic salmon Salmo salar L. J. Fish Dis. 25, 599-614.

    Vermeer, C., L. Braam, L. Schurgers, F. Brouns. (2002). Increased vitamin K intake by functional foods or food supplements: a new lead to improve cardiovascular and bone health. Agrofood Industry Hi-Tech 13, 11-15.

    Ketteler, M., Vermeer, C., Wanner, C., Westenfeld, R., Jahnen-Dechent, W., Floege, J. (2002). Novel insights into uremic calcification: role of Matrix Gla-Protein and α2-Hermans-Schmid Glycoprotein / fetuin. Blood Purif. 20, 473-476.

    Rubio-Gozalbo, M.E., Hamming, S., van Kroonenburgh, M.J.P.G., Bakker, J.A., Vermeer, C., Forget, P.Ph. (2002). Decreased bone mineral density in patients with classic galactosemia. Arch. Dis. Childh. 87, 57-60.

    Schurgers, L.J., Shearer, M.J., Soute, B.A.M., Elmadfa, I., Harvey, J., Wagner, K.-H., Tomasch, R., Vermeer, C. (2002). Novel effects of diets enriched with corn oil or with an olive/sunflowerseed oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men. J. Lipid Res. 43, 878-884.

    Houben, R.J.T.J., Rijkers, D.T.S., Stanley, T.B., Acher, F., Azerad, R., Käkönen, S.-M., Vermeer, C., Soute, B.A.M. (2002). Characteristics and composition of the vitamin K-dependent γ-glutamyl carboxylase binding domain on osteocalcin. Biochem. J. 364, 323-328.

    Schurgers, L.J., Vermeer, C. (2002). Differential lipoprotein transport pathways of K-vitamins in healthy subjects. Biochim. Biophys. Acta 1570, 27-32.

    Penning-van Beest, F.J.A., Geleinse, J.M., van Meegen, E., Vermeer, C., Rosendaal, F.R., Stricker, B.H.Ch. (2002). Lifestyle and diet as risk factors related to overanticoagulation. J. Clin. Epidemiol. 55, 411-417.

    Celie, P.H.N., van Stempvoort, G., Fribourg, C., Schurgers, L.J., Lenting, P.J., Mertens, K. (2002). The connecting segment between both epidermal growth factor-like domains in blood coagulation factor IX contributes to stimulation by factor VIIIa and its isolated A2 domain. J. Biol. Chem. 277, 20214-20220.

    Thijssen, H.H.W., Drittij, M.J., Vermeer, C., Schoffelen, E. (2002). Menaquinone-4 in breast milk is derived from dietary phylloquinone. Brit. J. Nutr. 87, 219-226.

    Dhore, C.R., Cleutjens, J.P.M., Lutgens, E., Cleutjens, K.B.J.M., Geussens, P., Kitslaar, P.J.E.H.M., Tordoir, J.H.M., Spronk, H.M.H., Vermeer, C., Daemen, M.J.A.P. (2001). Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscl. Thromb. Vasc. Biol., 21, 1998-2003.

    Spronk, H.M.H., Soute, B.A.M., Schurgers, L.J., Cleutjens, J.P.M., Thijssen, H.H.W., De Mey, J.G.R., Vermeer, C. (2001). Matrix Gla protein accumulates between tissue and calcium deposits in the arterial vessel wall, Biochem. Biophys. Res. Commun. 289, 485-490.

    Mousallem, M., Spronk, H.M.H., Sacy, R., Hakime, N., Soute, B.A.M. (2001) Congenital Combined Deficiencies Of All Vitamin K- Dependent Coagulation Factors. Thromb. Haemostas. 86, 1334-1336.

    Schurgers, L.J., Dissel, P.E.P., Spronk, H.M.H., Soute, B.A.M., Dhore, C.R., Cleutjens, J.P.M., Vermeer, C. (2001). Role of vitamin K and vitamin K-dependent proteins in vascular calcification. Z. Kardiol. 90:Suppl. 3, III/57-III63.

    Nieuwenhuys, C.M., Feijge, M.A., Vermeer, C., Hennissen, A.H., Beguin, S., Heemskerk, J.W. (2001) Vitamin K-dependent and vitamin K-independent hypocoagulant effects of dietary fish oil in rats. Thromb. Res. 104, 137-147.

    Vermeer, C., Braam, L. (2001) Role of K vitamins in the regulation of tissue calcification. J. Bone. Miner. Metab. 19, 201-206

    Schurgers, L.J., Vermeer, C. (2001) Corn oil-induced decrease in arterial thrombosis tendency may be related to altered plasma vitamin K transport. J. Lipid. Res. 42, 1120-1124.

    Farzaneh-Far, A., Davies, J.D., Braam, L.A., Spronk, H.M., Proudfoot, D., Chan, S.W., O'Shaughnessy, K.M., Weissberg, P.L., Vermeer, C., Shanahan, C.M. (2001) A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels.J. Biol. Chem. 276, 32466-32473.

    Schoon, E.J., Geerling, B.G., Van Dooren, I.M., Schurgers, L.J., Vermeer, C., Brummer, R.J., Stockbrugger, R.W. (2001). Abnormal bone turnover in long-standing Crohn's disease in remission. Aliment. Pharmacol. Ther. 15, 783-792.

    Hackeng, T.M., Rosing, J., Spronk, H.M.H., Vermeer, C. (2001)Total chemical synthesis of human matrix Gla protein. Proteine Science 10, 864-870.

    Schoon E.J., Muller M.C., Vermeer C., Schurgers L.J., Brummer R.J., Stockbrugger R.W. (2001) Low serum and bone vitamin K status in patients with longstanding Crohn's disease: another pathogenetic factor of osteoporosis in Crohn's disease? Gut 48, 473-477.

    Vermeer C., Thijssen H.H., Hamulyak K. (2001) Vitamin K and tissue mineralization. Bibl Nutr Dieta 55, 159-170.

    Oldenburg J., von Brederlow B., Fregin A., Rost S., Wolz W., Eberl W., Eber S., Lenz E., Schwaab R., Brackmann H.H., Effenberger W., Harbrecht U., Schurgers L.J., Vermeer C., Muller C.R. (2000) Congenital deficiency of vitamin K dependent coagulation factors in two families presents as a genetic defect of the vitamin K-epoxide-reductase-complex. Thromb Haemost 84, 937-941.

    Spronk H.M.H, Farah R.A., Buchanan G.R., Vermeer C., Soute B.A.M. (2000) Novel mutation in the gamma-glutamyl carboxylase gene resulting in congenital combined deficiency of all vitamin K-dependent blood coagulation factors. Blood 96, 3650-3652

    Gijsbers B.L., Vermeer C. (2000) Carrier-linked peptides as a reference compound in enzyme-linked immunosorbent assays. Anal Biochem 284, 430-432.

    Braam L.A., Dissel P., Gijsbers B.L., Spronk H.M.H., Hamulyak K., Soute B.A.M., Debie W.,Vermeer C. (2000) Assay for Human Matrix Gla Protein in Serum : Potential Applications in the Cardiovascular Field. Arterioscler Thromb Vasc Biol. 20, 1257-12611.

    Craciun A.M., Vermeer C., Eisenwiener H.G., Drees N., Knapen M.H. (2000) Evaluation of a bead-based enzyme immunoassay for the rapid detection of osteocalcin in human serum. Clin Chem. 46, 252-257.

    Koivu-Tikkanen T.J., Schurgers L.J., Thijssen H.H., Vermeer C. Intestinal, hepatic, and circulating vitamin K levels at low and high intakes of vitamin K in rats. Br J Nutr. 83, 185-190.

    Vermeer C., Schurgers L.J. (2000) A comprehensive review of vitamin K and vitamin K antagonists. Hematol Oncol Clin North Am. 14, 339-353