Vitak, Maastricht University
Innovative Medical Devices
Innovation & Research
MGP Center
Human Trial Center: ICHIS
Education
Measurements & Resources

1990-1999

  1. Houben, R. J. T. J., Jin, D., Stafford, D. W., Proost, P., Ebberink, R. H. M., Vermeer, C., Soute, B.A.M. (1999) Osteocalcin binds tightly to the g-glutamylcarboxylase at a site distinct from that of the other known vitamin K-dependent proteins. Biochem. J. 341, 265-269


    Schürgers, L.J., Geleijnse, J.M., Grobbee, D.E., Pols, H. A. P., Hofman, A., Witeman, J.C.M., Vermeer, C. (1999) Nutritional intake of vitamins K1 (phylloquinone) and K2 (menaquinone) in The Netherlands. Journal of Nutritional & Environmental Medicine 9, 115-122.


    Craciun, A. M., Wolf, J., Knapen, M. H., Brouns, F., and Vermeer, C. (1998). Improved bone metabolism in female elite athletes after vitamin K supplementation. Int J Sports Med 19, 479-84. Craciun, A. M., Groenen-van Dooren, M. M., Thijssen, H. H., and Vermeer, C. (1998). Induction of prothrombin synthesis by K-vitamins compared in vitamin K- deficient and in brodifacoum-treated rats. Biochim Biophys Acta 1380, 75-81.


    Knapen, M. H., Nieuwenhuijzen Kruseman, A. C., Wouters, R. S., and Vermeer, C. (1998). Correlation of serum osteocalcin fractions with bone mineral density in women during the first 10 years after menopause. Calcif Tissue Int 63, 375-9.


    Ronden, J. E., Drittij-Reijnders, M. J., Vermeer, C., and Thijssen, H. H. (1998). Intestinal flora is not an intermediate in the phylloquinone- menaquinone-4 conversion in the rat. Biochim Biophys Acta 1379, 69-75. Ronden, J. E., Thijssen, H. H., and Vermeer, C. (1998). Tissue distribution of K-vitamers under different nutritional regimens in the rat. Biochim Biophys Acta 1379, 16-22. Vermeer, C., Knapen, M. H., and Schurgers, L. J. (1998). Vitamin K and metabolic bone disease. J Clin Pathol 51, 424-6.


    Craciun, A. M., Groenen-van Dooren, M. M., and Vermeer, C. (1997). Nutritional vitamin K-intake and urinary gamma-carboxyglutamate excretion in the rat. Biochim Biophys Acta 1334, 44-50.


    Houben, R., Soute, B. A., Knapen, M. H., and Vermeer, C. (1997). Strategies for developing human osteocalcin standards: a critical evaluation. Scand J Clin Lab Invest Suppl 227, 100-4.


    Houben, R. J., Soute, B. A., and Vermeer, C. (1997). Assay of vitamin K-dependent carboxylase activity in hepatic and extrahepatic tissues. Methods Enzymol 282, 358-68.


    Ronden, J. E., Groenen-van Dooren, M. M., Hornstra, G., and Vermeer, C. (1997). Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. Atherosclerosis 132, 61-7.


    Gijsbers, B. L., Jie, K. S., and Vermeer, C. (1996). Effect of food composition on vitamin K absorption in human volunteers. Br J Nutr 76, 223-9.


    Jie, K. G., Bots, M. L., Vermeer, C., Witteman, J. C., and Grobbee, D. E. (1996). Vitamin K status and bone mass in women with and without aortic atherosclerosis: a population-based study. Calcif Tissue Int 59, 352-6.
    Knapen, M. H., Eisenwiener, H. G., and Vermeer, C. (1996). Osteocalcin detection in aging serum and whole blood: stability of different osteocalcin fractions. Clin Chim Acta 256, 151-64.


    Ronden, J. E., Soute, B. A., Thijssen, H. H., Saupe, J., and Vermeer, C. (1996). Natural prenylquinones inhibit the enzymes of the vitamin K cycle in vitro. Biochim Biophys Acta 1298, 87-94.


    Vermeer, C., Gijsbers, B. L., Craciun, A. M., Groenen-van Dooren, M. M., and Knapen, M. H. (1996). Effects of vitamin K on bone mass and bone metabolism. J Nutr 126, 1187S-91S.


    Groenen-van Dooren, M. M., Ronden, J. E., Soute, B. A., and Vermeer, C. (1995). Bioavailability of phylloquinone and menaquinones after oral and colorectal administration in vitamin K-deficient rats. Biochem Pharmacol 50, 797-801.


    Jie, K. S., Bots, M. L., Vermeer, C., Witteman, J. C., and Grobbee, D. E. (1995). Vitamin K intake and osteocalcin levels in women with and without aortic atherosclerosis: a population-based study. Atherosclerosis 116, 117-23.


    Jie, K. S., Gijsbers, B. L., and Vermeer, C. (1995). A specific colorimetric staining method for gamma-carboxyglutamic acid- containing proteins in polyacrylamide gels. Anal Biochem 224, 163-5.


    Jie, K. S., Knapen, M. H., Hellemons, B. S., Hamulyak, K., and Vermeer, C. (1995). [Vitamin K: current viewpoints in connection with bone metabolism]. Ned Tijdschr Geneeskd 139, 875-80.


    Vermeer, C., Jie, K. S., and Knapen, M. H. (1995). Role of vitamin K in bone metabolism. Annu Rev Nutr 15, 1-22.


    Buitenhuis, H. C., Soute, B. A., and Vermeer, C. (1990). Comparison of the vitamins K1, K2 and K3 as cofactors for the hepatic vitamin K-dependent carboxylase. Biochim Biophys Acta 1034, 170-5.


    Saupe, J., Ronden, J. E., Soute, B. A., and Vermeer, C. (1994). Vitamin K-antagonistic effect of plastoquinone and ubiquinone derivatives in vitro. FEBS Lett 338, 143-6.


    Groenen-van Dooren, M. M., Soute, B. A., Jie, K. S., Thijssen, H. H., and Vermeer, C. (1993). The relative effects of phylloquinone and menaquinone-4 on the blood coagulation factor synthesis in vitamin K-deficient rats. Biochem Pharmacol 46, 433-7.


    Jie, K. S., Gijsbers, B. L., Knapen, M. H., Hamulyak, K., Frank, H. L., and Vermeer, C. (1993). Effects of vitamin K and oral anticoagulants on urinary calcium excretion. Br J Haematol 83, 100-4.


    Knapen, M. H., Jie, K. S., Hamulyak, K., and Vermeer, C. (1993). Vitamin K-induced changes in markers for osteoblast activity and urinary calcium loss. Calcif Tissue Int 53, 81-5.


    Morris, D. P., Soute, B. A., Vermeer, C., and Stafford, D. W. (1993). Characterization of the purified vitamin K-dependent gamma-glutamyl carboxylase. J Biol Chem 268, 8735-42.


    Jie, K. S., Hamulyak, K., Gijsbers, B. L., Roumen, F. J., and Vermeer, C. (1992). Serum osteocalcin as a marker for vitamin K-status in pregnant women and their newborn babies. Thromb Haemost 68, 388-91.


    Soute, B. A., Groenen-van Dooren, M. M., Holmgren, A., Lundstrom, J., and Vermeer, C. (1992). Stimulation of the dithiol-dependent reductases in the vitamin K cycle by the thioredoxin system. Strong synergistic effects with protein disulphide-isomerase. Biochem J 281, 255-9.


    Soute, B. A., Ulrich, M. M., Watson, A. D., Maddison, J. E., Ebberink, R. H., and Vermeer, C. (1992). Congenital deficiency of all vitamin K-dependent blood coagulation factors due to a defective vitamin K-dependent carboxylase in Devon Rex cats. Thromb Haemost 68, 521-5.


    Vermeer, C., Knapen, M. H., Jie, K. S., and Grobbee, D. E. (1992). Physiological importance of extra-hepatic vitamin K-dependent carboxylation reactions. Ann N Y Acad Sci 669, 21-31; discussion 31-3.


    Soute, B. A., Bude, R., and Vermeer, C. (1991). Vitamin K-dependent carboxylation of poly-L-glutamate. Biochim Biophys Acta 1073, 434-6.


    Vermeer, C., and Hamulyak, K. (1991). Pathophysiology of vitamin K-deficiency and oral anticoagulants. Thromb Haemost 66, 153-9.


    Gijsbers, B. L., van Haarlem, L. J., Soute, B. A., Ebberink, R. H., and Vermeer, C. (1990). Characterization of a Gla-containing protein from calcified human atherosclerotic plaques. Arteriosclerosis 10, 991-5.


    Soute, B. A., Acher, F., Azerad, R., and Vermeer, C. (1990). Vitamin K-dependent carboxylase: effect of ammonium sulfate on substrate carboxylation and on inhibition by stereospecific substrate analogs. Biochim Biophys Acta 1034, 11-6.


    Vermeer, C. (1990). Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase. Biochem J 266, 625-36.


    Wu, S. M., Soute, B. A., Vermeer, C., and Stafford, D. W. (1990). In vitro gamma-carboxylation of a 59-residue recombinant peptide including the propeptide and the gamma-carboxyglutamic acid domain of coagulation factor IX. Effect of mutations near the propeptide cleavage site. J Biol Chem 265, 13124-9.