Vitamin K-deficiency may occur by either poor dietary vitamin K intake, disturbed intestinal uptake (e.g. caused by a bile duct obstruction), or by therapeutic or accidental intake of vitamin K-antagonists. As a result of the acquired vitamin K-deficiency, Gla-residues are not or incompletely formed and hence the Gla-proteins are inactive. Lack of control of the three processes mentioned above may lead to: 1. risk of uncontrolled and severe bleeding
sufficient vit K insufficient vit K
On the following pages we will describe in more detail our knowledge on vitamin K and vitamin K-dependent processes as well as new insights on human vitamin K requirement.